Pathology histology - Basal cell carcinoma

Pathology histology

Normal skin

Normal skin

Normal skin - Dermis

Normal skin - Epidermis

Normal skin - Hypodermis

Skin with basal cell carcinoma

• 2 skin slides

• Tumors in dermis and in connection with epidermis, but nothing in hypodermis

BCC - Apoptosis

BCC - Tumor lobule

• Relatively well circumscribed (malignant tumor with clearly defined, smooth borders)

• Large basaloid lobules with palisadation of the peripheral nuclei

• Situated within a fibromyxoid stroma

• Cells are basaloid (similar to cells in the base layer of the epidermis)

BCC - Cleft between tumor lobules and stroma/dermis

• Common finding in BCC

• Called cleft artefact

BCC - Tumor cells in connection with epidermis

BCC - Palisadation of the peripheral nuclei

• Palisadation = Alignment of elongated cell nuclei in parallel rows

• Seen in tumor lobules

BCC - Epidermis

BCC - Dermis

BCC - Hypodermis

BCC - Tumor stroma

• A bit fibrotic - more dense than normal tissue

• Black dots = Lymphocytes

BCC - Highly sun damaged skin

• Greyish mass → Sun damage

• Normally dermis is pink

Normal hair follicle within BCC skin

• Surrounded by subcutaneous glands