anti-TB drugs

anti-TB drugs

rifampin

what are rifampin’s unique adverse effects? discoloration of body fluids

can turn body fluids orange-red (urine, sweat, saliva, tears); can stain contact lenses (wear glasses instead)

how does this differ from phenazopyridine?

phenazopyridine (orange-red urine) rifampin (orange-red body fluids - urine, sweaat, saliva, tears)

what are rifampin’s unique adverse effects? CYP enzyme inducer

meaning decreased concentration of other drugs (rifampin speeds up liver enzymes that metabolize other drugs)

what meds could be affected from rifammpin being a CYP enzyme inducer?

oral contraceptives —> pregnancy risk; warfarin —> decreased anticoagulation effect, some HIV meds, some seizure meds; KNOW it decreases effectiveness of oral contraceptives; use backup birth control

what are rifampin’s unique adverse effects? common with all RIPE therapy

GI distress, hepatotoxicity

what is RIPE therapy?

common first-line TB: R = rifampin I = isoniazid P = pyrazinamide E = ethambutol WATCH THE LIVER