Blood Bank Final Review

AHG is an antibody that will bind to:

Other antibodies and/or complement (depending on type used)

Alloimmunization (first time exposure to an antigen) is very likely to cause an immediate transfusion reaction.

False.

IgG antibody attachment to red blood cells most often leads to what transfusion reaction?

Delayed hemolytic transfusion reaction

What class of immunoglobulin is most effective at initiating the complement cascade?

IgM

What immune system cell is responsible for identifying foreign antigens and initiating the alloimmunization process?

T helper cells

What is the OVERALL process whereby antibodies attached to red cell antigens, followed by the red blood cells being transported to the spleen for recycling/disposal?

Extravascular hemolysis

A patient requires specific phenotype of blood for which the combined phenotype probability is 0.26.

The patient requires 2 units.

How many units will you potentially need to screen to obtain the 2 units?

Enter your answer as a whole number. Round your calculated value UP from the decimal value to the next whole number.

Example: calculated number = 1.2 units --> round to 2.

8

An individual that is blood group Oh (Bombay) will demonstrate which of the following antigens on their RBC's?

No Antigens

Genes Jka and Jkb are most completely described as:

 

Antitheticals

What chromosome are the ABO genes found on?

9

A patient that is blood group AB can receive plasma from what blood groups?

AB

Which of the following blood groups is considered a UNIVERSAL DONOR with respect to RBC units?

O=

An A2 blood group individual MAY produce antibodies against A1 RBC antigen.

True

An individual of blood group A will have MORE H antigen present on the RBC surface than an individual of blood group AB.

True

An individual of blood group O will present with what RBC surface antigens?

H

Anti-A1 produced by an A2 blood group individual is clinically significant.

(this is to say that transfusing an A2 blood group individual with A1 blood may cause a dangerous reaction)

False

What immunodominant sugar goes with blood group antigen A?

N-acetylgalactosamine

What immunodominant sugar goes with blood group antigen B?

D-galactose

What immunodominant sugar goes with blood group antigen H?

L-fucose

What immunodominant sugar goes with blood group antigen O?

L-fucose

Blood group with the LEAST H antigen:

Oh (Bombay)

Blood group with the MOST H antigen:

O

What lectin is used to distinguish Bombay phenotype group O and regular group O?

Ulex europaeus

What lectin is used to distinguish from subgroup A1 from subgroup A2?

Dolichos biflorus

The "H" gene follows what inheritance pattern?

Dominant

The H antigen is coded in DNA via what gene?

FUT1

The chemical classification of the structure that defines a blood group antigen is:

Glycoprotein

The purpose of testing with anti-A,B reagent anti-sera is to detect:

 

Subgroups of A antigen

What genetic product is responsible for presentation of A and/or B antigens?

Transferases

To avoid alloimmunization, a patient with Fisher-Race phenotype:

DCE/DCe

Should not receive blood from a donor of what Wiener genotype?

R1r"

Which of the following Wiener genotypes demonstrates the Ce in trans to D effect?

R0r'

A single dose of RhIG (aka RhoD aka RhoGAM) will protect against what volume of fetal blood in maternal circulation?

30

HDFN due to a feto-maternal ABO incompatibility is typically more or less severe than HDFN due to an Rh incompatibility. 

ABO incompatibility HDFN is LESS severe than Rh incompatibility

Administration of RhIG immunoglobulin to prevent HDFN is an example of what form of immunization?

 Passive artificial

Antibodies against Kidd antigens are not of concern as a potential cause of HDFN.

False

Antibodies against which of the given antigens could lead to severe HDFN, but are of low concern due to the extreme rarity of them occuring?

U

Other than the D antigen, what particular Rh antigen is commonly associated with severe HDFN?

c (lower)

What antibody(ies) is(are) responsible for feto-maternal ABO incompatibilities?

Anti-A,B; IgG class

HDFN may lead to kernicterus in a newborn.

What is the clinical significance/meaning of kernicterus?

Accumulation of bilirubin in the brain

Which laboratory test would be used to determine if preterm early delivery is an appropriate option in the event of serious HDFN?

L:S ratio

Which laboratory test would be used to determine the extent of (fetal) HDFN and if intrauterine or preterm delivery options should be considered?

Spectrophotometric absorbance (OD) at 450 nm

Which of the following antibody classes is capable of crossing the placental barrier?

IgG

A missed field reaction on forward typing would most probably be observed in which situation?

Group A patient transfused with a large volume of Group O blood.

A patient demonstrates anti-E in their plasma.

Which of the following phenotyped red blood cell units would be acceptable for transfusion?

Dce/dce