LYMPHADENOPATHY AND INTRODUCTION TO LYMPHOMA - HODGKIN LYMPHOMA AND BURKITT LYMPHOMA

lymphadenopathy

enlargement of lymph nodes due to cellular proliferation in response to various stimulus

classification of lymphadenopathy

-NON NEOPLASTIC LYMPHADENOPATHY

NON NEOPLASTIC LYMPHADENOPATHY

A. NON SPECIFIC REACTIVE HYPERPLASIA

• location: lymph nodes near infection site

• due to pathogenic organism

B. SPECIFIC REACTIVE DISORDER

1. granulamatous lymphadenitis

• toxoplasmosis

• sarcoidosis, Crohns disease

• silicone compunds in plastic surgery and joint replacement

2. necrotizing lymphadenitis

• central abscess with rim/ palisade of macrophage

• STI related disease

• Cat-scratch disease

• Kikuchi’s disease

3. sinus histiocytosis (reticular hyperplasia)

• very common reaction

• increase number and size of endothelial cells lining lymphatic sinusoid

• increase intrasinusoidal macrophage

• example:

→ lymph nodes draining cancer

4. paracortical hyperplasia

• dermatopathic lymphadenopathy

→ chronic skin condition

→ in inguinal and axillary nodes -enlarged

• infectious mononucleosis

→ EBV

5. HIV infection

classification of lymphadenopathy

NEOPLASTIC LYMPHADENOPATHY

MALIGNANT LYMPHOMA

• Hodgkin lymphoma

• Non-Hodgkin lymphoma

• metastatic neoplasm

HODGKIN LYMPHOMA

• CLASSIFICATION

CLASSIC

1. nodular sclerosis

2. mixed cellularity

3. Lymphocyte-Rich

4. Lymphocyte-Depleted

clinical features of Hodgkin lymphoma and morphology

CLINICAL FEATURES

• bimodal age- young adult and middle aged adult

• more common in males

• painless lymphadenopathy

MORPHOLOGY

• lymph nodes enlarged

• homogenous and grey white cut surface

• firm, rubbery consistency

• nodular appearance (fibrous band) in nodular sclerosis sybtype

• abundant necrosis in mixed cellularity and lymphocyte depleted

SUBTYPE OF HODGKIN LYMPHOMA

BURKITT LYMPHOMA

• immunophenotype

IMMUNOPHENOTYPE

• surface IgM +

• CD19+

• CD20+

• CD10+

• BCL6+

BURKITT LYMPHOMA

• clinical features

MORPHOLOGY OF BURKITT LYMPHOMA