Ras/MAPK Pathway (Topic 6)

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Last updated 4:40 PM on 4/11/26
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4 Terms

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1.

Tyrosine Kinase Receptor (RTK) is activated

  • EGF binds to EGFR

<p>Tyrosine Kinase Receptor (RTK) is activated</p><ul><li><p>EGF binds to EGFR</p></li></ul><p></p>
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2.

Adaptor proteins are recruited to the receptor

  • GRB2 (via its SH2 domain)

<p>Adaptor proteins are recruited to the receptor</p><ul><li><p>GRB<sub>2</sub> (via its SH<sub>2</sub> domain)</p></li></ul><p></p>
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3.

Ras-GEF is recruited

  • Adaptor protein (GRB2) recruits Ras-GEF (called “SOS” in this pathway)

<p>Ras-GEF is recruited</p><ul><li><p>Adaptor protein (GRB<sub>2</sub>) recruits Ras-GEF (called “SOS” in this pathway)</p></li></ul><p></p>
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4.

When activated by binding to GRB2, SOS exchanges GDP for GTP on Ras

  • Ras (small G-protein) is now active

  • activates a kinase cascade

<p>When activated by binding to GRB<sub>2</sub>, SOS exchanges GDP for GTP on Ras</p><ul><li><p>Ras (small G-protein) is now active</p></li><li><p>activates a kinase cascade</p></li></ul><p></p>