Glutamate 3 - Presynaptic Mechanisms & Clearance

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Last updated 6:56 AM on 5/19/26
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6 Terms

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GLUT (Vesicular Glutamate Transporters)

Transporters responsible for loading glutamate into synaptic vesicles to segregate it for neurotransmission.

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EAATs (Excitatory Amino Acid Transporters)

A family of transporters on postsynaptic membranes and astrocytes responsible for clearing glutamate from the synaptic cleft.

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Consequence of Prolonged Glutamate Exposure

Over-excitation of neurons leading to cellular damage and cell death (excitotoxicity).

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Astrocytes

Star-shaped glial cells in the CNS that provide physical

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Glutamine Synthetase

The astrocyte enzyme that converts toxic glutamate into the safe precursor glutamine.

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The Glutamate-Glutamine Cycle

The process where astrocytes uptake glutamate