MEDILINK KISO

Inhibit DNA gyrase

inhibit topoisomerase IV

Block DNA replication or transcription

Ciprofloxacin

Target bacterial ribosomes and inhibit peptide elongation

50S subunit inhibitors

Azithromycin

Clindamycin

Block translation initiation/ tRNA binding

30S subunit inhibitors

Tetracycline

Gentamicin

Damage bacterial membrane integritt

Inserts into membrane → K leakage and cell death

Daptomycin

Block peptidoglycan formation, inhibit transpeptidase (PBP) → weak cell wall → bacterial lysis

Cephalosporins, penicillin, Vancomycin

blocks folate syntehsis (tetrahydrofolate)

inhibits dihydropteroate synthase

inhibits dihydrofolate reductase

ST combination

1. Sulfamethoxazole → inhibits dihydropteroate synthase

2. Trimethoprim → inhibits dihydrofolate reductase

Antimetabolites ( hydroxyurea) acts in ___ phase

S

Vincristine, Paclitaxel

Microtubule inhibitors

DNA damage before mitosis

Bleomycin

Cell cycle nonspecific, direct DNA damage

Cyclophosphamide, cisplatin

what are intermediate filaments made of

keratin, vimentin

what cytoskeleton works in transport, mitosis

microtubules

Fantastic Four

RAAS inhibition, Beta-blocker, Mineralocorticoid, SGLT2

TGFBR（TGF-β receptor）

大腸癌 増殖抑制

RB1

細胞周期の制御

C-MYC 核内転写活性蛋白

Burkittリンパ腫

N-MYC 核内転写活性蛋白

神経芽腫，肺小細胞癌

CCND1（Cyclin D1） 細胞周期制御

マントル細胞リンパ腫

APC/βカテニン

シグナル伝達阻害

NF1

シグナル伝達阻害と細胞周期阻害 神経線維腫症1型（von Recklinghausen病），肉腫

HNPCC（Lynch症候群）

ミスマッチ修復

MUTYH関連ポリポーシス

塩基除去修復（BER）

色素性乾皮症

ヌクレオチド除去修復（NER）