PKPD Exam 4 Cheeky Questions
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12 Terms
Which graph can show confidence intervals on exposure indices such as Cmax and AUC?
Forest Plot
What does the Metabolic Ratio for the CYP2D6 Debrisoquine Test represent?
Higher ratio = more drug, less metabolite, poorer metabolism
Which enzyme is the greatest Venlafaxine metabolizer?
CYP2D6
How does Theophylline clearance change with age?
Rapid increase during first year with gradual fall off towards middle age
What trend is seen on PharmacoDYNAMICS with age?
No clear trend
Why do males have almost double the clearance of Metoprolol over females?
higher CYP2D6 activity
Which is not a substrate of CYP1A2
Lorazepam
Which is not a true statement?
Obese women should be cautioned with using Plan B due to decreased metabolism
Which enzyme is responsible for metabolizing Nicotine into Cotinine
CYP2A6
Which CYP enzyme is most at risk for genetic variability?
CYP2D6
Which statement about smoking and metabolism is not true?
An individual with lower Thiocyanate (SCN-) levels would experience greater Theophylline clearance
Which statement about Inflammation is correct?
RA symptoms are worse in the morning due to high IL-6 levels