Transmission Modulators

What does L-Dopa do?

crosses blood brain barrier and is metabolized into dopamine

How does L-Dopa enhance communication?

enhancing synthesis or packaging of NT

What condition is L-dopa used to treat

Parkinsons

What medications have an effect on neurotransmitter-gated ion channels?

benzodiazepine and Barbiturate

What happens with benzodiazepine (valium/diazepam)

increases the frequency of opening of GABA-gated Cl- channels

What happens with Barbiturate

increase the duration GABA-gated Cl- channels

What drug has effects on G-protein cou0led neurotransmitter receptors

morphine

what does morphine do

mimics opioid peptides, binds to their receptors, causes analgesia and other effects

What drugs enhance by blocking removal of neurotransmitter

fluoxetine (prozac) and cocaine

What does fluoxetine (prozac) do

blocks serotonin reuptake

what does cocaine do

blocks reuptake of norepinephrine and dopamine

What drug block degradation of neurotransmitter

pyridostigmine (mestinon)

What does pyridostigmine do

blocks acetylcholinesterase

What is pyridostigmine used to treat

myasthenia gravis

What drugs interfere with NT release

botulinum and tetanus toxin

What does botulinum toxin do

blocks release of acetylcholine causing flaccid paralysis

What does tetanus toxin do

blocks release of glycine causing rigid paralysis

What drugs effect G protein-coupled NT receptors

Haloperidol and Atropine

What does haloperidol do

antipsychotic, blocks dopamine receptors

What does atropine do

blocks muscarinic acetylcholine receptors, causing autonomic changes (blocks vagus nerve, increases HR)