LAB EVAL OF SECONDARY HEMOSTASIS

A screening coagulation test commonly ordered when unfractionated heparin is monitored and performed using citrated platelet-poor plasma with phospholipid and activator reagents.

Activated Partial Thromboplastin Time

What is the reagent/activator of the test that measures all the factors except Proconvertin and Plasma transglutaminase?

Thromboplastin - Proconvertin is Factor VII and Plasma transglutaminase is Factor XIII and the test described is APTT

This clotting test uses a tube with no anticoagulant present

Capillary tube method

Which clotting assay evaluates coagulation using non-anticoagulated blood rather than platelet-poor plasma, relying on sequential tube observation for clot formation?

Lee and White Whole Blood Coagulation Time

Which clotting test requires the sample to be incubated at physiologic temperature and is commonly used in patients undergoing heparin therapy?

Activated Clotting Time

A disorder defined by quantitative deficiency of Factor I, affecting clot formation.

Hypofibrinogenemia

A coagulation procedure in which citrated plasma clots only after the reintroduction of calcium ions. Identify the test.

Plasma Recalcification Test

A clotting assay performed on platelet-poor plasma that requires an activator, phospholipid, and calcium before timing fibrin formation. Identify the test.

Activated Partial Thromboplastin Time

A coagulation test/assay used to follow treatment with an oral anticoagulant whose action resembles vitamin K deficiency

Warfarin Assay

A coagulation test used for monitoring oral anticoagulant therapy and does not detect deficiency of plasma thromboplastin component

Quick’s Test

Prothrombin time

This activator is used for the test that determines the deficiency of vitamin-K dependent group

Simplastin

What test is the standardized report of Prothrombin Time?

International Normalized Ratio

If the common pathway has a defect, what would be the laboratory findings?

Prolonged APTT and PT

If the defect is in intrinsic pathway, which test is prolonged?

APTT only

In which test is prolonged if the problem is in the extrinsic pathway?

PT only

A coagulation test used to differentiate Factor VII deficiency from Factor X deficiency, particularly when PT is prolonged but the venom-based test remains normal. Identify the test.

Stypven’s time

Diluted Rusell Viper Venom Test

What is the reagent used on the test that is venom-based?

Vipera russelli

Fibrinogen levels of 72 indicates what result?

Prolonged Thrombin Time

A fibrinogen test using an enzyme derived from snake venom and unaffected by heparin.

Reptilase Test

A stability assay where a formed clot fails to persist when exposed to thrombin

Duckert’s assay
5M Urea Solubility Test

Incubation temperature for the test that uses known factor VII as reagent

37^oC

A laboratory method assessing vWF-dependent platelet agglutination using a compound historically known as an antibiotic.

Ristocetin Cofactor Assay

Note: also uses aggregometer

A coagulation assay in which a prolonged APTT becomes normal after about 10 minutes of incubation, indicating deficiency of a contact activation factor. Identify the test.

Fletcher Factor Assay

A factor analysis technique in which patient plasma corrects the clotting time of plasma lacking a specific coagulation factor.

One-Stage Quantitative Clotting Assay

Which laboratory procedure is suggested when APTT corrects after incubation, pointing to a deficiency of prekallikrein?

Fletcher Factor Assay

The result of this test is expressed in ratio

Tissue Thromboplastin Test

Which test measures the strength of antibodies that inactivate Factor VIII by determining how much factor activity remains after incubation?

Bethesda Inhibitor Assay

Which test detects the autoantibodies on patients with Systemic Lupus Erythematosus?

Platelet Neutralization Test