para 2 The Impact of Cancer Genetics on Targeted Therapies
Call Kai
Learn
Practice Test
Spaced Repetition
Match
Flashcards
Knowt Play1/41
There's no tags or description
Looks like no tags are added yet.
Name | Mastery | Learn | Test | Matching | Spaced | Call with Kai |
|---|
No analytics yet
Send a link to your students to track their progress
42 Terms
para 2
The Impact of Cancer Genetics on Targeted Therapies
The Impact of Cancer Genetics on Targeted Therapies layout 1
what targeted therapies aim to do
The Impact of Cancer Genetics on Targeted Therapies layout 2
oncogenes
The Impact of Cancer Genetics on Targeted Therapies layout 3
tumour suprressor genes
The Impact of Cancer Genetics on Targeted Therapies layout 4
examples of successes of this approach
The Impact of Cancer Genetics on Targeted Therapies questions 1 what targeted therapies aim to do
what do targeted therapies aim to exploit
The Impact of Cancer Genetics on Targeted Therapies questions 2 what targeted therapies aim to do
where do most adult malignant tumours come from
The Impact of Cancer Genetics on Targeted Therapies questions 3 what targeted therapies aim to do
what is this concept known as
The Impact of Cancer Genetics on Targeted Therapies what targeted therapies aim to do what do targeted therapies aim to exploit
the underlying molecular pathogenesis of a tumour.
The Impact of Cancer Genetics on Targeted Therapies what targeted therapies aim to do where do most adult malignant tumours come from
the accumulation of sequential mutations in specific oncogenes and tumour suppressor genes
The Impact of Cancer Genetics on Targeted Therapies what targeted therapies aim to do what is this concept known as
Vogelstein’s multi-step model.
The Impact of Cancer Genetics on Targeted Therapies what targeted therapies aim to do full sentence 1
Targeted therapies aim to exploit the underlying molecular pathogenesis of a tumour.
The Impact of Cancer Genetics on Targeted Therapies what targeted therapies aim to do full sentence 2
Most adult malignant tumours arise from the accumulation of sequential mutations in specific oncogenes and tumour suppressor genes
The Impact of Cancer Genetics on Targeted Therapies what targeted therapies aim to do full sentence 3
a concept known as Vogelstein’s multi-step model.
The Impact of Cancer Genetics on Targeted Therapies oncogenes questions 1
what are they activated by
The Impact of Cancer Genetics on Targeted Therapies oncogenes questions 2
example
The Impact of Cancer Genetics on Targeted Therapies oncogenes questions 3
what do they provide
The Impact of Cancer Genetics on Targeted Therapies oncogenes what are they activated by
"hotspot" gain-of-function mutations,
The Impact of Cancer Genetics on Targeted Therapies oncogenes example
PIK3CA or EZH2,
The Impact of Cancer Genetics on Targeted Therapies oncogenes what do they provide
which provide a selective growth advantage to the cell
The Impact of Cancer Genetics on Targeted Therapies oncogenes full sentence 1
These are activated by "hotspot" gain-of-function mutations, such as PIK3CA or EZH2, which provide a selective growth advantage to the cell
The Impact of Cancer Genetics on Targeted Therapies Tumour Suppressor Genes: questions 1
what do they require to lose function
The Impact of Cancer Genetics on Targeted Therapies Tumour Suppressor Genes: questions 2
what is this two hits to lose function known as
The Impact of Cancer Genetics on Targeted Therapies Tumour Suppressor Genes: questions 3
examples
The Impact of Cancer Genetics on Targeted Therapies Tumour Suppressor Genes: questions 4
how are they found in the majority of cancers
The Impact of Cancer Genetics on Targeted Therapies Tumour Suppressor Genes: what do they require to lose function
These typically require "two hits" to lose function
The Impact of Cancer Genetics on Targeted Therapies Tumour Suppressor Genes: what is this two hits to lose function known as
(Knudson’s hypothesis),
The Impact of Cancer Genetics on Targeted Therapies Tumour Suppressor Genes: examples
such as TP53 or RB1,
The Impact of Cancer Genetics on Targeted Therapies Tumour Suppressor Genes: how are they found in the majority of cancers
which are inactivated in the majority of human cancers
The Impact of Cancer Genetics on Targeted Therapies Tumour Suppressor Genes: full sentence 1
These typically require "two hits" to lose function (Knudson’s hypothesis), such as TP53 or RB1, which are inactivated in the majority of human cancers
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach questions1
what do successes of this approach include
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach questions2
imatinib other name
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach questions3
what is imatinib or gleevec used to target
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach questions4
what is the other name for trastuzumab
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach questions5
what is trastuzumab or herceptin used for
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach what do successes of this approach include
the use of Imatinib (Gleevec) and Trastuzumab (Herceptin)
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach imatinib other name
(Gleevec)
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach what is imatinib or gleevec used to target
to target the BCR-ABL translocation in Chronic Myeloid Leukemia (CML)
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach what is the other name for trastuzumab
(Herceptin)
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach what is trastuzumab or herceptin used for
for patients with HER2 amplification in breast cancer.
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach CML
Chronic Myeloid Leukemia
The Impact of Cancer Genetics on Targeted Therapies examples of successes of this approach FULL SENTENCE 1
Successes of this approach include the use of Imatinib (Gleevec) to target the BCR-ABL translocation in Chronic Myeloid Leukemia (CML) and Trastuzumab (Herceptin) for patients with HER2 amplification in breast cance