[LADME] Metabolism - Phase I - CYP450 enzymes

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Proverbs 16:3

Last updated 5:49 PM on 5/19/26
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33 Terms

1
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● 1A2

● 2C9

● 2D6

● 3A4

CYP450 enzymes include _____ [4]

2
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● Theophylline

● Acetaminophen

[SUBSTRATES]

1A2

3
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● Phenytoin

● Warfarin

[SUBSTRATES]

2C9

4
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Many cardiovascular and CNS drugs

[SUBSTRATES]

2D6

5
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60% of drugs in PDR

[SUBSTRATES]

3A4

6
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● Aromatic hydrocarbons (smoke)

● Cruciferous vegetables

[INDUCERS]

1A2

7
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● Anticonvulsants (barbiturates, phenytoin, carbamazepine)

● Antibiotics (rifampin)

● Chronic alcohol

● St. John's Wort.

[INDUCERS]

2C9

8
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None known

[INDUCERS]

2D6

9
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● Anticonvulsants (barbiturates, phenytoin, carbamazepine)

● Antibiotics (rifampin)

● Chronic alcohol

● St. John's Wort.

[INDUCERS]

3A4

10
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● Quinolones

● Macrolides

[INHIBITORS]

1A2

11
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None known

[INHIBITORS]

2C9

12
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● Haloperidol

● Quinidine

[INHIBITORS]

2D6

13
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● Antiulcer medications (cimetidine, omeprazole)

● Antimicrobials (chloramphenicol, macrolides, ritonavir, ketoconazole)

● Acute alcohol

● Grapefruit juice

[INHIBITORS]

3A4

14
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No

[GENETIC POLYMORPHISM - YES OR NO]

1A2

15
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Yes

[GENETIC POLYMORPHISM - YES OR NO]

2C9

16
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Yes

[GENETIC POLYMORPHISM - YES OR NO]

2D6

17
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No

[GENETIC POLYMORPHISM - YES OR NO]

3A4

18
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1A2

[CLASSIFY - SUBSTRATE]

Theophylline

19
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1A2

[CLASSIFY - SUBSTRATE]

Acetaminophen

20
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2C9

[CLASSIFY - SUBSTRATE]

Phenytoin

21
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2C9

[CLASSIFY - SUBSTRATE]

Warfarin

22
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2D6

[CLASSIFY - SUBSTRATE]

Many cardiovascular and CNS drugs

23
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3A4

[CLASSIFY - SUBSTRATE]

60% of drugs in PDR

24
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1A2

[CLASSIFY - INDUCERS]

Aromatic hydrocarbons (smoke)

25
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1A2

[CLASSIFY - INDUCERS]

Cruciferous vegetables

26
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● 2C9

● 3A4

[CLASSIFY - INDUCERS]

General inducers:

● Anticonvulsants (barbiturates, phenytoin, carbamazepine)

● Antibiotics (rifampin)

● Chronic alcohol

● St. John's Wort.

27
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2D6

[CLASSIFY - INDUCERS]

None known

28
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1A2

[CLASSIFY - INHIBITORS]

Quinolones

29
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1A2

[CLASSIFY - INHIBITORS]

Macrolides

30
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2C9

[CLASSIFY - INHIBITORS]

None known

31
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2D6

[CLASSIFY - INHIBITORS]

Haloperidol

32
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2D6

[CLASSIFY - INHIBITORS]

Quinidine

33
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3A4

[CLASSIFY - INHIBITORS]

General inhibitors:

● Antiulcer medications (cimetidine, omeprazole)

● Antimicrobials (chloramphenicol, macrolides, ritonavir, ketoconazole)

● Acute alcohol

● Grapefruit juice