Cell Bio Extracellular Matrix
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20 Terms
What is the extracellular matrix?
A diverse group of molecules secreted by cells that are not passive, but rather dynamic
What is Ehlers-Dani’s syndrome?
Group of disorders that affect the joints and skin
Who as Ehlers-Danlos syndrome no has spoken out about it?
Lena Dunham and singer Sia
What are the functions of the ECM?
Enhancing cell adhesion,
Is ECM important to tissue engineering such as Epiderm?
Very important!
What is homophilic cell adhesion?
It binds to a partner that is the exact same ex. Cadherins
What is heterophilic cell adhesion?
It binds to a partner that is different in structure ex. Integrins
What is multiadhesive linker cell adhesion?
It binds to a partner via a multiadhesive
What are N Cadherins?
Neura
What are E Cadherins?
Epithelial
What are P Cadherins?
Placental
How many types of Cadherins are there?
About 12
What are Cadherins?
they work in cis-trans interactions
Require calcium in 5 different domains
Important for both development and tissue compaction
How can we prove Cadherins are homophilic?
they use L-cells, they are not substrate independent
They float in cell culture, they don’t express Cadherins
They transfer cells with Cadherins gene
The result is that the cells adhere to each other in cluster in presence of calcium, they dissociate without it
Take Cadherin-expressing L-cells and present them with non expressed L-cells, if they stick then Cadherins are binding to something other than the Cadherins, if not then they are homophilic