Neoplasia Colon Cancer

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Last updated 9:52 PM on 4/13/26
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8 Terms

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Osteoma
Skin Cysts
Polyps

Gardner Syndrome

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Polyps
CNS Tumors (Ej: Medulloblastoma)

Turcot Syndrome

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APC mutation + KRAS + p53

Invasive Adenocarcinoma (adenoma carcinoma sequence)

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APC mutation in colon

Familial Adenomatous Polyposis
- Gardner Synd
- Turcot Synd
- Invasive adenocarcinma (+KRAS +p53)

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APC Mutation Pathogenesis

APC loss = Increase B-Catenin
More than 100 Polyps in colon.

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Microsatellite instability (MSH2)

Lynch Syndrome (HNPCC)

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Right sided colon cancer with endometrial cancer
Familial (few polyps)

Lynch syndrome (HNPCC)

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Variant of Lynch Syndrome with skin tumors (sebaceous adenoma)

Muir Torre Syndrome