breast pathology

mammary gland normal composition

Myoepithelial cells: SMA+

Luminal cells PR+

BREAST FIBROCYSTIC CHANGE

elastic, mobile, vaguely nodularity of breast tissue

On cut section an increase in dense, fibrous stroma and some degree of cystic

dilatation of the terminal ducts

BREAST FIBROCYSTIC CHANGE

elastic, mobile, vaguely nodularity of breast tissue

On cut section an increase in dense, fibrous stroma and some degree of cystic

dilatation of the terminal ducts

white areas are fibrosis, and black holes are cystic dilatation

BREAST FIBROCYSTIC CHANGE

Cysts: simple or with

apocrine metaplasia

BREAST FIBROCYSTIC CHANGE

Cysts: simple or with

apocrine metaplasia

BREAST FIBROCYSTIC CHANGE

Cysts: simple or with

apocrine metaplasia

BREAST FIBROCYSTIC CHANGE

BREAST FIBROCYSTIC CHANGE

elastic, mobile, vaguely nodularity of breast tissue

On cut section an increase in dense, fibrous stroma and some degree of cystic

dilatation of the terminal ducts

white areas are fibrosis, and black holes are cystic dilatation

also some atrophic calcification

BREAST FIBROCYSTIC CHANGE

BREAST FIBROCYSTIC CHANGE

interstitial fibrosis

BREAST FIBROCYSTIC CHANGE

normal aspect of the mammary gland

BREAST FIBROCYSTIC CHANGE

apocrine metaplasia of the duct

BREAST FIBROCYSTIC CHANGE

dilated cystic ducts

Breast carcinoma

most common malignant tumor of women

majorit y are carcinom as

types

•in situ

•infiltrative

Gross

aspects of infiltrativ e carcinom a

Hard nodule 2 5 cm Ø, no define borders,

irregular contour, adherences with

sorrounding structures

On section tough firm, grey shiny,

sometimes with yellowish flecks like ripe

pear pulp)

breast carcinoma

breast carcinoma

breast carcinoma

comedo

DCIS infiltrative

carcinoma NST ( ductal microscopy)

Breash carcinoma DCIS

intermingled with infiltrative carcinom a NST, poorly differentiated

•basement membrane of ducts: continuous / preserved

•central necrosis in dilated ducts

nests

ribbons of malignant

epithelial cells within a focally

dense fibrous stroma adipose

tissue infiltration

Breast carcinoma

invasive carcinoma

NST is

graded using the Nottingham

histologic score

•tubule formation (gland s

75% = scor e 1, 10 75% =

scor e 2, 10% = scor e 3),

•mitoses / 10HPF (scor e : 1

3)

•nuclear pleomorphism

(scor e : 1 3)

• Grade I (G1): Score of \(3\), \(4\), or \(5\). These are considered well-differentiated; the cells closely resemble normal breast tissue and tend to grow slowly. [1]

• Grade II (G2): Score of \(6\) or \(7\). These are considered moderately differentiated; the cells show more abnormalities and grow at a moderate rate. [1, 2]

• Grade III (G3): Score of \(8\) or \(9\). These are considered poorly differentiated; the cells look very disorganized and tend to grow and divide more rapidly. [1, 2, 3, 4, 5]

infiltrative breast carcinoma

Breast carcinoma

breast carcinoma

normal aspect of glands

breast carcinoma DISC comedo

intruductal abundant pasty tumoral necrosis

breast cancer

intact basal membrane

breast carcinoma

intact basal membrane

breast carcinoma

ductral infiltration

breast cancer

ductal infiltration