2. Evidence Not Supporting Brenner’s Statement (Pro-Sirtuin Perspective)

What do proponents like David Sinclair argue about sirtuins?

That sirtuins are essential for maintaining the epigenome. (David Sinclair)

What do sirtuins protect according to the Information Theory of Aging?

The "digital information" of the cell from "scratches" (DNA damage). (David Sinclair)

What happens when cells get DNA damage?

They lose their identity. (David Sinclair)

What recent studies were done on SIRT6?

SIRT6 transgenic mice. (Shin-ichiro Imai)

What did SIRT6 transgenic mice show?

Dramatic lifespan extension in both males and females. (Shin-ichiro Imai)

What does this suggest about some sirtuin family members?

They may indeed be potent longevity regulators in mammals. (Shin-ichiro Imai)

What do proponents argue about sirtuin activation and healthspan?

That it improves metabolic markers like insulin sensitivity and mitochondrial biogenesis. (Shin-ichiro Imai)

What else does sirtuin activation counteract?

Diseases of aging. (Shin-ichiro Imai)

What is the key distinction proponents make?

Sirtuin activation improves healthspan even if it does not always extend maximum lifespan. (Shin-ichiro Imai)

1

. Evidence Not Supporting Brenner’s Statement (Pro-Sirtuin Perspective)

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Information Theory of Aging

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Potency of SIRT6

4

Healthspan vs. Lifespa