CD4 T Cells and T Helper Subsets

Flashcards on CD4 T cells, T helper cell subsets, and related concepts.

T Cells

Lymphocytes that mature in the thymus and can become either CD4 positive or CD8 positive.

Thymus

The organ where T cells mature and undergo positive and negative selection.

T Cells

Lymphocytes that mature in the thymus and can become either CD4 positive or CD8 positive.

Thymus

The organ where T cells mature and undergo positive and negative selection.

Lymph Nodes and Spleen

Secondary lymphoid organs where naive T cells look for their cognate antigen.

CD4 T Cells

T cells that recognize exogenously processed peptides presented on MHC class II molecules.

Co-stimulatory Signal

A co-stimulatory molecule delivered through CD28, required for optimal T cell response.

Specialized Subsets

CD4 T cells differentiate into these in response to microbial stimulation.

TH1 Cells

T helper cells that produce interferon-gamma and TNF.

TH2 Cells

T helper cells that produce interleukin-4, interleukin-5, interleukin-6, and interleukin-10.

Interferon-gamma

The major signature cytokine of TH1 response that activates macrophages.

IL-4 (Interleukin-4)

The key signature cytokine for TH2 cells, contributing to class switching to IgE.