NAS reaction summary

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Last updated 7:48 AM on 4/30/26

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23 Terms

1

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acyl chloride → acid anhydride

RCOO^-(base-catalyzed/basic conditions)

2

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acyl chloride → carboxylic acid

H₂O

3

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acyl chloride → ester

ROH

4

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acyl chloride → amide

2 equiv. RNH₂

5

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acid anhydride → ester

ROH

6

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acid anhydride → carboxylic acid

H₂O

7

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acid anhydride → amide

2 equiv. RNH₂

8

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carboxylic acid → acyl chloride

PCl₃ or SOCl₂

9

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carboxylic acid → ester

ROH (acid-catalyzed)

10

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carboxylic acid → amide

RNH_2, heat

11

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carboxylic acid → acid anhydride

heat or P₂O₅

12

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carboxylic acid → carboxylate

base

13

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ester → carboxylic acid

H₂O (acid-catalyzed)

H₂O, OH^- (base-catalyzed/basic conditions)

14

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ester → amide

RNH₂, heat

15

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ester → ester

ROH (acid-catalyzed)

ROH, RO^- (base-catalyzed/basic conditions)

16

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amide → ester

ROH, heat (acid-catalyzed)

17

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amide → carboyxlic acid

H₂O, heat (acid-catalyzed)

18

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amide → carboxylate

H₂O, OH^- (base-catalyzed/basic conditions)

19

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carboxylate → carboxylic acid

acid

20

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carboxylate → acyl chloride

PCl₃ or SOCl₂ with heat

21

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nitrile → amide

H₂O, heat (acid-catalyzed)

22

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nitrile → amine

H₂, Raney Ni

23

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alkyl halide → amine

Gabriel synthesis