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glucose is used for the building of _____, the basic nutrient and energy for a cell
ATP (adenosine triphosphate)
aerobic respiration produces wastes that cause the body to form _____
acids - essentially all waste is managed and removed from the body
anaerobic respiration produces what
lactic acid (from pyruvic acid)
what process moves oxygen across the membrane from the alveoli to the capillaries
diffusion
the removal of _____ _____ helps regulate acid levels in the body
carbon dioxide
effects of the release of epinephrine and norepinephrine
dilation of bronchial tubes, more efficient gas exchange, faster heart rate/cardiac output, some constriction of blood vessels to non-essential organs (regarding flight or fight response)
how much nitrogen and oxygen is in inhaled air
79% nitrogen ; 21% oxygen ; very low % other gases
FiO2 refers to fraction of inspired oxygen, what is this
the concentration of oxygen in the air we breathe
a patent airway is a(n)
open, non-obstructed airway
tidal volume
the amount of air moved in ONE cycle of breathing
minute volume
tidal volume (air breathe in) * number of respiration’s per minute = the amount of air moved in a minute
dead air space refers to the
air that occupies the space between the alveoli and mouth, but DOES NOT take part in gas exchange
three types of respiratory dysfunctions
disruption of: respiratory control, pressure, and lung tissue
disruption of respiratory control
effects on the medulla oblongata (strokes, drugs, toxins, trauma, etc.) that cause the medulla oblongata to effectively regulate respiratory control and tidal volume
disruption of thoracic pressure on respiration
affects the negative pressure created in the thoracic cavity needed to adequately provide ventilations (blood/fluid, air accumulation due to trauma can cause collapsed lungs and a decrease in adequate pressure)
inhalation is a _____ process, creating _____ pressure, thus forcing air into the lungs
active ; negative
exhalation is a _____ process, creating _____ pressure, thus forcing air out of the lungs
passive ; positive
changing pressures changes for proper respiration relies on an intact _____ _____
thoracic (chest) compartment
disruption of lung tissue
when lung tissue is displaced or destroyed via mechanical force, causing ineffectiveness in gas exchange (particularly that of the alveoli membrane)
what medical problems commonly causes disrupt the ability of alveoli to transfer gases across its membranes, leading to hypoxia and hypercapnia
congestive heart failure (CHF) and sepsis
hypoxia
low oxygen levels within the body
hypercapnia
high carbon dioxide levels within the body
chemoreceptors send messages to the brain to increase __________
rate and/or tidal volume
plasma oncotic pressure
pulls water back into the bloodstream from surrounding tissues (albumin protein in blood plasma) is the biggest contributor)
hydrostatic pressure
pushes water out of the vessels and into the interstitial space between cells
plasma makes up _____ , erythrocytes make up _____ , and luekocytes make up _____ of total blood volume
54% ; 45% ; 1%
blood vessel dysfunctions
loss of tone, excessive permeability, hypertension, loss of regulation
loss of blood vessel tone
inability of blood vessels to control their diameter. Uncontrolled vaso- dilation or constriction that can lead to drastic pressure changes within the blood vessels themselves
what is excessive permeability in relation to blood dysfunction
when blood vessels, caused by certain conditions, allow to much fluid to flow out through their walls
leaky capillaries may lead to
volume loss from the bloodstream
increased permeability in the lungs can cause
plasma to cross the membrane and occupy space around the alveoli, causing disruptions in airflow and gas-exchange
how can hypertension lead to blood dysfunction
certain conditions cause abnormal constriction of the blood vessels increasing pressure the heart has to work against to pump blood (SVR)
systemic vascular resistance (SVR)
the pressure in the peripheral blood vessels the blood has to overcome to pump blood into the system
how can loss of regulation lead to blood dysfunction
an absence of messengers to vaso- dilate or constrict can lead to dropping of circulatory system pressure and shock
stroke volume
amount of blood ejected from the heart in one contraction (~ 70 ml of blood per contraction)
preload
how much blood is returned to the heart or how much the heart is filled - greater the filling of the heart = the greater the stroke volume
contractility
force of contraction - more forceful contractions = greater stroke volume
afterload
how much pressure the heart has to pump against to force blood into the circulatory system - greater the pressure = greater the stroke volume
three components that affect stroke volume
preload, contractility, and afteload
cardiac output
amount of blood ejected from the heart in one minute (HR * stroke volume)
bradycardia and steep tachycardia both tend to _____ cardiac output
decrease (although a slight increase in heart rate tends to INCREASE heart rate, i.e. exercise)
children lack the contractile muscles to regulate the force of the squeeze, to compensate, children _____ _____ _____ to compensate for poor perfusion
increase heart rate
a V/Q (ventilation/perfusion) match is
the alveoli is supplied with enough air and that air is sufficiently being exchanged with blood in the pulmonary capillaries
the opposite of a V/Q math is a _____ _____, or hypoperfusion (or shock)
V/Q mismatch
when does hypoperfusion (shock) occur
when the regular delivery of oxygen and nutrients to cells, and removal of their waste products, are interrupted
four groups of shock categories are
hypovolemic, distributive, cardiogenic, and obstructive
hypovolemic shock
low blood volume - occurs when blood is lost from the cardiovascular system decreasing pressure heart has to pump blood adequately through the body (ex. severe bleeding, dehydration)
distributive shock
blood vessel tone (ability to control diameter) is lost - lowers pressure, blood cannot efficiently be pumped (ex. anaphylaxis, sepsis)
cardiogenic shock
heart fails in its ability to pump blood - cardiac output fails, hypoperfusion occurs (ex. myocardial infarction, trauma, damage to heart muscle (mechanical) )
obstructive shock
blood is physically prevented from flowing - large quantities of blood cannot reach essential organs and vital areas (ex. tension pneumothorax, pericardial tamonade, pulmonary embolism)
compensated shock
when the body adjusts for shock (hypoperfusion) - primarily through a sympathetic NS response
inadequate compensation for shock results in the body falling into _____
decompensated shock
irreversable shock
failure to compensate for shock, often leads to death
signs and symptoms of compensated shock
altered LOC, increased HR, increased respiratory rates, delayed capillary refill time (>2 seconds), diaphoresis (pale/clammy/cool/moist skin), sweating
_____ percent of the body weight stems from _____
60 ; water (divided into intercellular, intravascular, and interstitial)
disruptions in fluid balance can occur in what two ways
dehydration (loss of fluid), and poor fluid distribution (edema)
the greater the injury or trauma, the greater the shift in _____
fluid distribution - especially when pressure is high
ways in which the nervous system can become disrupted
trauma and medical dysfunction
medical dysfunction in the nervous system can be in what forms
infection (meningitis) or general medical problems (low blood sugar)
digestive disorders can drastically lead to impacts on both _____ and _____
fluid balance ; nutrient transfer
hypersensitivity
extreme exaggeration response by the immune system to a particular substance
infancy age is from
birth to 1 year
toddler age is from
12-36 months
preschool age is from
3-5 years
school age is from
6-12 years
adolescence age is from
13-18 years
early adulthood age is from
19-40 years
middle adulthood age is from
41-60
late adulthood age is from
61+ years
the glottic opening is the boundary between the _____ and the _____ airways at the level of the vocal cords
upper ; lower
the trachea bifurcates into the two mainstem bro
carina
What are the airway differences between children and adults regarding mouth/nose size?
Children's mouth/nose are smaller, which makes them more easily obstructed.
How does the size of the tongue affect children's airways?
The tongue in children takes up more space in the mouth, which can easily obstruct the airway
What unique breathing characteristic do newborns and infants have?
Newborns and infants breathe through their nose, not their mouth. Nasal obstruction can lead to airway impairment.
How does the structure of the trachea differ in children?
The trachea in children is softer, more flexible, and narrower, resulting in a higher risk of obstruction from swelling and foreign objects.
What is a characteristic of the chest wall in infants?
the chest wall in infants is softer, and they depend more on their diaphragm for breathing
what is a common cause of airway obstruction in unconscious patients
the tongue/epiglottis falling back over the trachea due to loss of muscle control
a semi-unconscious and unconscious patient are more susceptible to airway obstruction in what position and are required to be continually monitored
the supine position
stridor
a high pitched ‘whistling’ sound usually caused by a severely restricted upper airway (ex. foreign object or swelling of upper airway)
hoarseness
voice change/raspy voice and an indication of swelling - an ominous sign that the airway will eventually likely close over time
snoring
soft tissue overlaping the upper airway (i.e. the tongue and epiglottis) - indication of loss of muscle tone and that the airway needs assistance opening
snoring can be normal unless in the case of _____ and _____
injury/trauma ; illness
gurgling
indication that the airway is obstructed via fluid/secretions (i.e. blood/vomit/liquids) - immediate suctioning is necessary
sounds of a partially obstructed airway
stridor, hoarsness, snoring, and gurgling
in order, what questions must be asked when assessing a patients airway
is the patient breathing → is the airway open → will the airway stay open →
signs of inadequate breathing
no signs of breathing/air movement
evidence of foreign objects/fluids in airway
no air can be felt or heard through nose or mouth
patient is unable to speak/has difficulty speaking
patients voice is unusually hoarse/raspy
minimal/uneven chest rise and fall
abdominal breathing
diminished/absent breath sounds
strange noises noted (stridor, hoarseness, etc.)
is children, what particularly is a sign of an inadequate airway not usually seen in adults
muscle retractions (pulling in of muscles above clavicle/ribs) and nasal flaring at the nose
ventilation
breathing in and out (inhalation and exhalation)
inhalation is an _____ process, while exhalation is a _____ process
active ; passive
normal tidal volume
5-7 ml per kg of body weight
ventilation does not always mean the patient is actively doing _____ and exchanging gases in the alveoli
respirations
alveolar ventilation
the amount of air that reaches the alveoli
diffusion
movement of gas from high to low concentration - oxygen and carbon dioxide diffusion takes place in the alveoli
pulmonary respiration (external respiration)
exchange of oxygen and carbon dioxide between circulating blood in the pulmonary capillaries
cellular respiration (internal respiration)
exchange of oxygen and carbon dioxide between cells and circulating blood
a patient who is stabbed in the chest, is unable to create _____ _____ in the chest due to air rushing into the stab wound
negative pressure - which makes it unable to pull air through the airway passages
respiration refers to the
exchange of gas between the alveoli and the blood
ways to check for hypoxia
pulse ox, capillary refill time
respiratory distress (adequate breathing)
difficulty breathing or cannot breath comfortably (compensating)
characterized by: shortness of breath or rapid breathing
respiratory failure (inadequate breathing)
the respiratory system fails in removing carbon dioxide from blood and oxygenating blood
characterized by: increased hypoxia, build up of carbon dioxide, and respiratory muscles tire