NSAIDS

SALICATES

ASPIRIN - IRREVERIBLE

DIFUSINAL - REVISIBLE

ARYLPROPIONINC ACID- COX 1 INHIBITOR- INHIBIT PROSTAGLANDINS

IBUPORFEN

NAPORXEN

FLUBOPRFEN

ARELYTIC ACID

KETORLAC- HIGH EFFICACY USED TO TREAT KIDNEY STONES

ETODORLAC- COX 2 SELECTIVNESS

NAMBUTRONE- PRODRUG, LESS GI EROSION

OXICAM DERIVITIVE

RX ONLY

COX 2 INHIBITORS- REDUCE INFLAMMATION

CELECOXIB

RODECOXIB

VALEOCOXIB

*NO GI EROSION SINCE IT KEEPS COX 1 INTACT THAT CREATE PROSTAGLANDINS TO PROTECT GI TRACT

NSAIDS INFO

BOUND TO PLASMA ALBUMIN

ELIMINATION IS RETARDED IN ELDERLY

HIGH INSTANCE OF OVERDOSE IN ELDERLY- SALCICYM- DONT GO TO DOCTOR UNTIL LATE SIGNS BC SIGNS INDICATE TO TAKE MORE MEDICATION

-K ANATAGONIST- ANTICOAGULANT EFFECT, IPAIRMENT OF PLATELET AGGREGATION

NSAIDS ADVERSE

CONTRAINDICATED IN LIVER FAILURE PTS DUE TO ROUTE OF METABOLISM

CONTRAINDICATED IN ASTHMA PTS BC INCREASED MAST CELLS AND LEUKOTRIENE SYNTHESIS

INTERACTIONS -

INCREASE WARAFIN ANTICOAUGULANT EFFECTS BC OF COMEPETETION FOR PLASMA ALBUMIN

MORE WARAFIN IN THE BLOOD BC IT DOES NOT METABLOIZE

BLUNT EFFECTS OF LOOP THIAZIDE DIRETICS DUE TO COMPETETION FOR PROXIMAL TUBLE SECRETION

ACETAMINOPHEN

-GIVEN TO KIDS WITH FEVER AND NOT ASPRIN BC IT CAUSES REYES SYDROME

MOA UNKNOWN

ELIMINATION IS ALSO RETARDED IN ELDERLY

HIGH DOSES INDICATE NECROTIC DAMAGE INCREASED WTIH ALC CONSUMPTION

ACTEOLCYSTEINE- ACTEAMINOPHEN OVERDOSE TREATMENT

INCREASES GLUTHION PRODUCTION

NEW OPIOID ANAGLESIC

SUZETRAZINE

• INCREASED BLOOD CREATNINE/ RASHES/ITCHING

• CONTRAINDICATED IN HORMONAL BC