pyruvate dehydrogenase complex

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Last updated 1:26 PM on 3/10/26
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4 Terms

1
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E1

requires cofactor TPP, departure of CO2 leaves a hydroxyethyl group attached to TPP

2
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E2

TPP is regenerated & the hydroxyethyl; group is oxidized to form an acetyl group

3
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E2 then

transfers the acetyl group to coenzyme A; acetyl-CoA is generated and E2 is left with s reduced lipoamide group

4
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pyruvate dehydrogenase deficiency causes

less NADH and FADH2 to be generated → less ATP is produced; accumulated pyruvate is reduced to lactate → acidosis