Immunology Exam 3 Diseases, Reaction Types, etc.

Myasthenia Gravis reaction type

II

Myasthenia Gravis Auto-Ab

Anti-acetylcholine receptor

Myasthenia Gravis Auto-Ag

Acetylcholine receptors

Graves’ Disease reaction type

II (hyperthyroidism)

Graves’ Disease auto-Ab

anti-TSH receptor

Graves’ Disease auto-Ag

TSH (thyroid stimulating hormone) receptor

SLE (Systemic Lupus Erythematosus) reaction type

III

SLE auto-Ab

Anti-dsDNA, anti-ssDNA, anti-RNA

SLE auto-Ag

dsDNA, ssDNA, RNA (cell nucleus components)

Hashimoto’s Thyroiditis reaction type

II (hypothyroidism)

Hashimoto’s Thyroiditis auto-Ab

Anti-TP and anti-TG

Hashimoto’s Thyroiditis auto-Ag

Thyroid peroxidase and thyroglobulin

Multiple Sclerosis reaction type

IV

Multiple Sclerosis auto-Ab

T1/T17

Multiple Sclerosis auto-Ag

Myelin exposure after trauma / cross-reactivity to viral Ag

Type I Diabetes reaction type

II

Type I Diabetes auto-Ag

Insulin and/or B-cells

Rheumatoid Arthritis reaction type

III and IV

Rheumatoid Arthritis auto-Ab

anti-IgG, anti-IgM, and rheumatoid factor (RF)

Rheumatoid Arthritis auto-Ag

abnormal IgG

Psoriasis reaction type

IV

Psoriasis auto-Ab

T1/T17

Psoriasis auto-Ag

LL-37 overproduction; over expressed neutrophil-produced antimicrobial peptide

Inflammatory Bowel Disease reaction type

II and IV

Inflammatory Bowel Disease auto-Ag

normal flora bacteria in intestine from loss of self tolerance

Addison’s Disease reaction type

II and IV

Addison’s Disease auto-Ag

21-hydroxylase enzyme in cortisol and aldosterone

Pernicious Anemia reaction type

II (B-12 deficiency)

Pernicious Anemia auto-Ab

intrinsic factor Ab and anti-parietal Ab

Pernicious Anemia auto-Ag

intrinsic factor and parietal cells

Celiac Disease reaction type

II and IV

Celiac Disease Auto-Ag

transglutamate mutation in gliadin peptide - fits into MHC II receptor

IL 12

Activates Tctl (cell-mediated immunity)

IL 2

Growth factor for T cells to proliferate and clone (2)

IL 4

Activates Th cells, B cells (humoral immunity)