[ANALYSIS-LAB-FIN-03-PT2] DISSOLUTION TESTING APPARATUS

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THIS FLASHCARDS IS ABOUT [ANALYSIS] DISSOLUTION.

QUALITY ANALYSIS

QUALITY CONTROL

Last updated 2:20 PM on 4/14/26
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18 Terms

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  1. Cylindrical flat bottom glass vessels

  2. Reciprocating cylinders

  3. Stainless steel fittings

TYPE 3 — RECIPROCATING CYLINDER:

Design: Vessel

  • Set of (1)____ flat bottom ___ vessels

  • Set of (2) reciprocating _____

  • (3)________ steel fittings

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  1. Reciprocating (upward & downward)

  2. 200-250 mL

  3. Cylinder

TYPE 3 — RECIPROCATING CYLINDER:

  1. What is the agitation type of the apparatus?

  2. What is the volume of dissolution medium of the apparatus?

  3. Where is the dosage form placed in the apparatus?

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37 ± 0.5°C

TYPE 3 — RECIPROCATING CYLINDER:

Design: Water Bath

  • It maintains at what temperature (°C)?

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  • Tablets

  • Beads

  • Controlled and extended release formulations

TYPE 3 — RECIPROCATING CYLINDER:

  • This is used for what dosage forms (3)?

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Reservoir

TYPE 4 — FLOW THROUGH CELL:

  • This is for the dissolution medium

<p><strong><u>TYPE 4 — FLOW THROUGH CELL</u>:</strong></p><ul><li><p>This is for the <strong>dissolution medium</strong></p></li></ul><p></p>
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Upward

TYPE 4 — FLOW THROUGH CELL:

  • The pump forces dissolution medium through cell in what direction?

<p><strong><u>TYPE 4 — FLOW THROUGH CELL</u>:</strong></p><ul><li><p>The <strong>pump </strong>forces dissolution medium through cell in what <u>direction</u>?</p></li></ul><p></p>
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  1. 10-100 mL/min

  2. Laminar flow

  3. Centrifugal pumps

TYPE 4 — FLOW THROUGH CELL:

Design: Pump

  1. What is the flow rate of the pump?

  2. What flow is maintained by the pump?

  3. What kind of pumps are not recommended?

<p><strong><u>TYPE 4 — FLOW THROUGH CELL</u>:</strong></p><p></p><p><strong>Design: </strong>Pump</p><ol><li><p>What is the <strong>flow rate</strong> of the pump?</p></li><li><p>What <strong>flow</strong> is maintained by the pump?</p></li><li><p>What kind of <strong>pumps</strong> are not recommended?</p></li></ol><p></p>
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37 ± 0.5°C

TYPE 4 — FLOW THROUGH CELL:

Design: Water Bath

  • It is maintained at what temperature (°C)?

<p><strong><u>TYPE 4 — FLOW THROUGH CELL</u>:</strong></p><p></p><p><strong>Design: </strong>Water Bath</p><ul><li><p>It is maintained at what temperature (°C)?</p></li></ul><p></p>
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  • Low solubility drugs

  • Microparticulate

  • Implants

  • Suppositories

  • Controlled release formulations

TYPE 4 — FLOW THROUGH CELL:

  • This is used for what dosage forms (5)?

<p><strong><u>TYPE 4 — FLOW THROUGH CELL</u>:</strong></p><ul><li><p>This is used for what dosage forms (5)?</p></li></ul><p></p>
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  1. Same as paddle apparatus

  2. 25-50 rpm

TYPE 5 — PADDLE OVER DISK:

  1. What is the vessel & shaft of the apparatus?

  2. What is the rotation speed of the apparatus?

<p><strong><u>TYPE 5 — PADDLE OVER DISK</u>:</strong></p><ol><li><p>What is the <strong>vessel &amp; shaft</strong> of the apparatus?</p></li><li><p>What is the <strong>rotation speed</strong> of the apparatus?</p></li></ol><p></p>
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Sample Holder

TYPE 5 — PADDLE OVER DISK:

  • A disk assembly that holds product in such a way that release surface is parallel with paddle blade.

<p><strong><u>TYPE 5 — PADDLE OVER DISK</u>:</strong></p><ul><li><p>A <strong>disk assembly</strong> that holds product in such a way that release surface is <strong>parallel with paddle blade.</strong></p></li></ul><p></p>
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25 ± 2 MM

TYPE 5 — PADDLE OVER DISK:

  • What is the distance?

    • (Samples are drawn between surface of the medium and the top of the paddle blade)

<p><strong><u>TYPE 5 — PADDLE OVER DISK</u>:</strong></p><ul><li><p>What is the <strong>distance?</strong></p><ul><li><p><em>(Samples are drawn between surface of the medium and the top of the paddle blade)</em></p></li></ul></li></ul><p></p>
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  1. 32 ± 0.5°C

  2. Transdermal products and emulsions

TYPE 5 — PADDLE OVER DISK:

  1. It is maintained at what temperature (°C)?

  2. This apparatus is used for what dosage forms (2)?

<p><strong><u>TYPE 5 — PADDLE OVER DISK</u>:</strong></p><ol><li><p>It is maintained at what t<strong>emperature (°C)?</strong></p></li><li><p>This apparatus is used for what <strong>dosage forms (2)?</strong></p></li></ol><p></p>
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Gikapoy nako boi

TYPE 6 — ROTATING CYLINDER:

<p><strong><u>TYPE 6 — ROTATING CYLINDER</u>:</strong></p>
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Gikapoy nako boi

TYPE 7 — RECIPROCATING-HOLDER:

<p><strong><u>TYPE 7 — RECIPROCATING-HOLDER</u>:</strong></p>
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  1. Purified water

  2. Dilute acid

  3. Stimulated gastric fluid (SGF)

  4. Stimulated intestinal fluid (SIF)

  5. Surfactants (e.g., Polysorbate, SLS)

  6. Aqueous buffers

What are the (6) Commonly Used Dissolution Media?

Hint: PDS-SSA

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  1. 1897

  2. Noyes and Whitney

  3. Benzoic acid

  4. Lead chloride

Conclusion:

Dissolution research started to develop in (1)____ when (2)_____ and _____ derived their equation in the course of their dissolution studies on (3)____ acid and (4)____ chloride.

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Basaha nalang brah

<p></p>