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- Heredity & Consumption, Prenatal Development, Birth & the Newborn Baby
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Heredity
Based on biological transmission of traits and characteristics from one generation to another
Genetics
Branch of biology that studies heredity
Genetic (Inherited) Influences
physical traits
Intelligence, emotional, and personality traits
Behavioral traits and psychological issues
Chromosomes
Found in cells
23 pairs of rod-shaped structures
Genes
Segments within chromosomes
Regulate development of traits
transmitted by single gene or may be polygenic
20,000 to 25,000 genes in every cell
DNA
Large strands make up genes
double spiral (helix)
Composed of phosphate and simple sugar
Base pairs adenine with thymine (A - T) or cytosine with guanine (C - G)
Mitosis
Cell division by which growth occurs and tissues are replaced
Stands of DNA break apart, duplicate, and are rebuilt
Result is identical copies of DNA strand
mutations are the exception
Meiosis
Cell division by which sperm and ova are produced
23 chromosomes pairs divide
Result is a new cell with only 23 chromosomes
22 pairs are autosomes
23rd pair are sex chromosomes
determines sex: X from mother and X or Y from father
Monozygotic (Identical) Twins (MZ)
Derived from a single zygote that has split in two
Dizygotic (Fraternal) Twins (DZ)
Derived fro, two zygotes
Share 50% of genetic material
Probability of twins increases:
Maternal age - less regular ovulation
Use of fertility drugs
What are Dominant and Recessive Traits?
Traits are determined by pairs of genes
each member of pair is an allele
Homozygous
Both alleles for a traits are the same
Heterozygous
Alleles for a trait are different
Gregor Mendel
Established the laws of heredity
Averaging
effects of both alleles are shown
incomplete dominance or codominance
law of Dominance
Dominant allele paired with recessive allele
Dominant allele appears in offspring
Chromosomes or genetic abnormalities
Occur in outcomes or sex chromosomes
May be caused by a single gene or combinations
Multifactorial problems
Chromosomal Abnormalities: Down Syndrome
Cause: extra chromosomes on 21st pair
Probability increases with increased age of parent
Characteristics:
facial features
deficits in cognitive, language, and motor development
Adjustment problems
Male with extra sex chromosome
XYY: extra Y chromosome
XXY: Klinefelter syndrome
Female with abnormal number of sex chromosomes
X: Turner syndrome
XXX: Triple X syndrome
Genetic Abnormalities
Phenylketonuria (PKU)
Huntington Disease
Sickle-cell anemia
Tay-sachs disease
Cystic fibrosis
Carried on X sex chromosome
Hemophilia
Duchenne muscular dystrophy
Diabetes
Color blindess
Some type of night blinds
Genetic Counseling
Addresses probability of genetic abnormalities
Information about couple’s genetic heritage
Prenatal testing
Amniocentesis
Chronic villus sampling (CVS)
Ultrasound
Blood tests
Amniocentesis
usually performed on mother about 14-16 wks after conception
Can detect more than 100 chromosomal and genetic abnormalities in fetus
Indicates the sex of the baby
Some risk of miscarriage
Improved ultrasound and blood tests is reducing use of amniocentesis
Chronic Villus Sampling (CVS)
Can diagnosis abnormalities earlier than amniocentesis
Equal or slightly higher risk of miscarriage, compared to amniocentesis
Ultrasound
Sonogram “picture” of fetus
Used to track fetus growth and to determine age, sex, and structural abnormalities
Blood tests
Can reveal presence of recessive genes in parents
Alpha-Fetoprotein (AFP) assay
Reaction Range
Range of possibilities for the expression of the trait
Genotypes
Phenotypes
Genotypes
Sets of traits inherited from parents
Phenotypes
Actual sets of traits
Product of genetic and environmental influences
Canalization
Environmental influences on genotype within reaction range
Canalization = sequence of development is invariant
Infant motor development
Less canalization
Intelligence
Personality
Genetic - Environmental Correlation
Passive Correlation
Evocative Correlation
Active Correlation
Passive Correlation
Environment that child is placed into
Evocative Correlation
Child’s genotype elicits responses
Active Correlation
Environment child chooses
Epigenetic framework
Development reflects the continual bidirectional exchanges between genetics and environmental influences
Kinship Studies
Genetic closeness of relatives
Twin Studies
Monozygotic twins share 100% of genes
Dizygotic twins share 50% of genes (same as siblings)
Reared together versus reared apart
Conception
ovarian follicle ruptures releasing the egg
Hundreds of millions of sperm are ejaculated
only a few thousands survive through the cervix
a few hundred bombard the ovum in the fallopian
Sperm and ovum unite
Ova
Begin to mature at puberty
Monthly release of mature egg into fallopian tube
Egg is propelled by cilia and, perhaps, by contractions in the wall of the fallopian tube
If not fertilized, egg is discharged along the endometrium
Sperm Cells
Each contains 46 chromosomes, including one X and one Y
Self propelled and smaller than ova
Sperm with Y chromosome swim faster than sperm with X chromosomes
more boys are conceived than girls
From 200 to 400 million in ejaculate; only 1 in 1000 arrive in vicinity of ovum
Attracted by chemical odor secreted by ova
Sperm must penetrate gelatinous layer around ova
What are causes of Infertility among men?
low sperm count
Deformed sperm
Diseases
Injury of testes
Autoimmune responses
Causes: Genetic factors, environmental poisons, diabetes, STI’s, overheating tests, pressure to tests, aging, and drugs
What are causes of Infertility among females?
Irregular or absence of ovulation
fertility drugs are used to cause women to ovulate
Declining hormone levels due to aging
Endometriosis
Obstructions or malfunctions of reproductive tract
Causes:
Hormone irregularities
Stress
Malnutrition
Infections that produce obstructions, as from scarring
Pelvic inflammatory disease
How are couples with fertility problems assisted?
Artificial Insemination
In Vitro Fertilization
Donor IVF
Surrogate Mothers
Adoption
Artificial Insemination
Sperm injected into mother’s uterus
In Vitro Fertilization
Ova and sperm are fertilized, then implanted in mother’s uterus
Donor IVF
Ovum harvested from donor woman; fertilized in vitro and implanted in recipient’s uterus
Embryonic transplant
Surrogate Mothers
“Substitute” who carries a baby to term for another woman
Ethical and legal risk because the surrogate mother may not want to give up the baby
Adoption
greater diversity of adopted children and adoptive parents
Consideration of adopted children needs
Relinquishing mothers also experience effects