General MOL

Xenon‑133 MOL

Localizes via gas exchange in alveoli (inhaled inert gas)

Tc‑DTPA (aerosol) MOL

Localizes by aerosol deposition in airways and alveoli

Tc‑MAA MOL

Localizes by capillary blockade in pulmonary arterioles (particle trapping)

Tc‑HDP MOL

Localizes by chemisorption to hydroxyapatite in bone

Tc‑MDP MOL

Localizes by chemisorption to hydroxyapatite in bone

Tc‑Sulfur Colloid (bone marrow) MOL

Localizes in reticuloendothelial system of bone marrow

In‑111 Oxine WBC MOL

Localizes by migration of tagged leukocytes to infection/inflammation

Tc‑Pertechnetate (joint) MOL

Localizes via diffusion into synovium and blood pool activity

Ga‑67 Citrate MOL

Localizes by binding transferrin; accumulates in inflammation and tumors

Filtered Sulfur Colloid (lymphoscintigraphy) MOL

Localizes via lymphatic uptake and transport

I‑123 Ioflupane (DaTscan) MOL

Localizes by binding dopamine transporters in the striatum

Tc‑DMSA MOL

Localizes in renal cortex via proximal tubular binding

Tc‑MAG3 MOL

Localizes via tubular secretion (effective renal plasma flow)

I‑123 Sodium Iodide MOL

Localizes via active transport through sodium‑iodide symporter (NIS)

Tc‑Sestamibi MOL

Localizes via mitochondrial uptake in hyperfunctioning parathyroid tissue

Tc‑Pertechnetate (thyroid) MOL

Localizes via trapping by NIS (not organified)

I‑131 Sodium Iodide MOL

Localizes via NIS uptake and organification in thyroid tissue

Lu‑177 Dotatate MOL

Localizes by binding somatostatin receptor subtype 2 (SSTR2)

Lu‑177 PSMA MOL

Localizes by binding prostate‑specific membrane antigen

Ra‑223 Dichloride MOL

Localizes as a calcium mimetic in areas of increased bone turnover

Sr‑89 Chloride MOL

Localizes by incorporation into bone matrix at sites of osteoblastic activity

Y‑90 Microspheres MOL

Localize via arterial embolization into hepatic tumors