comparation of different viral vectors summary chart

retroviral viral genome

- RNA

retroviral cell division requirement for target cell

- yes

retroviral packaging limitation

- 8 Kb

retroviral immune responses to vector

- few

retroviral genome integration

- yes

retroviral long-term expression

- yes

retroviral main advantages

- persistent gene transfer in dividing cells

lentiviral viral genome

- RNA

lentiviral cell division requirement for target cell

- G1 phase

lentiviral packaging limitation

- 8 kb

lentiviral immune responses to vector

- few

lentiviral genome integration

- yes

lentiviral long-term expression

- yes

lentiviral main advantages

- persistent gene transfer in transduced tissues

adenoviral viral genome

- DNA

adenoviral cell division requirement for target cell

- no

adenoviral packaging limitation

- 8 to 30 kb

adenoviral immune responses to vector

- extensive

adenoviral genome integration

- poor

adenoviral long-term expression

- no

adenoviral main advantages

- highly effective in transducing various tissues

AAV viral genome

- DNA

AAV cell division requirement for target cell

- no

AAV packaging limitation

- 5 kb

AAV immune responses to vector

- few

AAV genome integration

- poor

AAV long-term expression

- yes

AAV main advantages

- elicits few inflammatory responses, nonpathogenic