Nucleophilic acyl substitution

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Last updated 6:44 PM on 4/17/26
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15 Terms

1
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Carboxylic acid + alcohol →

Ester

2
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Acid chlorides & hydrides

No acid/base needed for hydrolysis

3
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Hydrolysis basic conditions

Carboxylate formed

4
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Ester, amide nitrile

Need acid/base catalyst for hydrolysis

5
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Acid chloride + carboxylate →

Anhydride

6
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Acid chloride + alcohol →

Ester

7
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Acid chloride + amide →

Amine

8
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Anhydride + alcohol →

Ester

9
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Anhydride + amine →

Amide

10
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Ester + amine →

Amide

11
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Ester—R + R’—OH (excess) →

Ester—R’

12
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Amide —H2O→

Acid

13
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Amide —POCl3→

Nitrile

14
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Amide —POCl3→

Nitrile

15
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Nitrile + H2O (excess) →

Carboxylic acid or carboxylate