Adverse Drug Reactions: Drug Induced GI Disorders

What is Adverse Drug Reactions

An unintended harmful reaction resulting from the use of a medicinal product

What’s the difference between ADR and side effects

•A side effect is an expected and known effect of a drug that is not the intended therapeutic outcome.

•ADRs are harmful and more unexpected. 

How is ADR classified

By Extended Rawlins- Thompson classification

State and explain the two types of Extended Rawlins- Thompson Classification

Type A reactions- ‘ dose-dependent’ and predictable on the basis of the pharmacology of the drug

Type B reactions- bizarre reactions- which are distinctive and not predictable on the basis of the pharmacology

explains the classification DoTS

Dose of the drug

Time course of the reaction

Response of Susceptibility factors

What are the general factors affecting ADRs Susceptibility

Age and Gender

Co-morbidities and concomitant medicines use

Pharmacogenetics

G6PD deficiency

Porphyria

What are the resources for identifying signs and symptoms

Clinical trial data

Case reports

Epidemiological studies