Module 2 Med List

Heparin

~Side Effects: Hemorrhage (hypotension, tachycardia), Epidural/spinal hematoma, Thrombocytopenia, Hypersensitivity (fever/chills/urticaria)

~Special Considerations: Reversal is protamine sulfate, Monitor aPTT, Pregnancy C category

Enoxaparin

~Side Effects: Hemorrhage, Thrombocytopenia

Warfarin

~Side Effects: Hemorrhage, Hepatitis

~Special Considerations: Reversal is Vitamin K, Avoid excessive green leafy vegetables. Monitor INR. Therapeutic range is 2-3. Avoid use with phenobarbital, carbamazepine, phenytoin, and oral contraceptives

Clopidogrel (Plavix)

~Side Effects: Bleeding, GI effects

~Special Considerations: Use cautiously in those with peptic ulcer disease or severe kidney or liver impairment

Alteplase, Tenecteplase, Reteplase

~Side Effects: Bleeding (Internal/external)

~Special Considerations: Limit venipunctures. Apply pressure dressings. Not used for hemorrhagic stroke

Levodopa-Carbidopa

~Side Effects: N/V, drowsiness, dyskinesis, orthostatic hypotension, tachycardia, psychosis

~Special Considerations: Avoid use with haloperidol. Do not use with MAOIs

Entacapone

~Side Effects: GI upset, discoloration of urine, rhabdomyolysis, liver failure

~Special Considerations: Monitor Liver panel

Selegiline, Rasagiline

~Side Effects: Insomnia, Hypertensive crisis, Nausea, Diarrhea

~Special Considerations: Avoid tyramine/use of MAOIs

Phenobarbital

~Side Effects: CNS effects, Toxicity (nystagmus, ataxia, respiratory depression, coma, pinpoint pupils)

~Special Considerations: Avoid with use of alcohol, benzodiazepines, and opioids

Phenytoin

~Side Effects: CNS effects, Gingival hyperplasia, Skin rash, Dysrhythmias, Hypotension

~Special Considerations: Therapeutic range 10-20 (serum)

Carbamazepine

~Side Effects: CNS effects, Leukopenia, Anemia, Thrombocytopenia, Hyperosmolality, Skin disorders

Valproic Acid

~Side Effects: GI Effects, Hepatotoxicity, Pancreatitis, Thrombocytopenia

Levetiracetam

~Side Effects: Dizziness, Weakness, Agitation, Anxiety, Depression

Gabapentin

~Side Effects: Dizziness, Ataxia, Fatigue, Nystagmus, Peripheral edema

Azathioprine, Cyclosporine

~Side Effects: Monitor for infection, Hypertension, Kidney dysfunction

~Special Considerations: Monitor WBC, BUN, and creatinine

Tizanidine, Baclofen

~Side Effects: Weakness, Hepatotoxicity, CNS depression

~Special Considerations: Do not abruptly stop baclofen!!

Diphenhydramine

~Side Effects: Drowsiness, Sedative effects if used in combination with other sedating drugs

~Special Considerations: Reduces urticaria/swelling, Used for EPS, Parkinsons, Dystonia, Used to pre-medicate/allergicreactions