Pt 4 Pharmacology of Synaptic Transmission
Call Kai
Learn
Practice Test
Spaced Repetition
Match
Flashcards
Knowt Play1/7
There's no tags or description
Looks like no tags are added yet.
Name | Mastery | Learn | Test | Matching | Spaced | Call with Kai |
|---|
No analytics yet
Send a link to your students to track their progress
8 Terms
What is the effect of a drug that acts as a NT precursor and what is an example of this?
Will increase the rate of synthesis
L-DOPA taken orally can increase the rate of dopamine synthesis
What is the effect of a drug inhibiting the enzyme for synthesis of a NT?
A decrease of the NT levels
Tyrosine inhibits tyrosine hydroxylase, decreasing DA levels
Can some drugs block NT breakdown
Yes
Can drugs block reuptake? Which drug
Yes, cocaine blocks the reuptake of monoamine NTs (DA, NE) so effects are longer lasting
What happens when drugs block the storage of NTs in vesicles?
Leave NT vulnerable to breakdown
How do drugs stimulate the release of a NT?
By reversing actions other than AP, like reuptake
What happens when drug stimulate vs inhibit autoreceptors (which signal how much NT is present in synapse)
Stimulating decreases release while inhibiting increases the release
What are the two ways drugs act on postsynaptic receptors when they have affinity for that NT at the binding site?
Agonist: mimics the NT effect
Antagonist: inhibits the effect of the NT