Bioinorganic (scattered) - L1&2 (Q1)

What do the macrominerals K & Mg do

Play structural role in stabilising the negative charges of DNA phosphate groups

What are 2 metal ions of the s block that are essential to life

Na+ and Ca+

What are 2 metal ions of the d block that are essential to life

Fe2+ and Cu2+

Which metal ions are typically found bonded to each of the following ligands; chlorophyll, coenzyme F430, heme, cobalamin.

Mg2+, Ni2+, Fe2+, CO2+

Is Fe(III) hard or soft?

Hard

Is Fe (II) hard or soft

Soft

Is Fe+ hard or soft

Soft

What is the concentration of K+ ion in the cytoplasm?

0.3M

What is the concentration of the K+ ion in the bloodstream

0.005M

K+ channels are responsible for transporting K+ in what direction?

From Inside to outside

Why is Zn2+ not a useful metal ion to be used in the electron transport chain

Redox inactive - 2+ is its only stable oxidation state (electron transport requires the ability to accept + donate electrons by switching oxidation states)

What kind of donor atoms would bind to essential metals from the s block?

What two amino acids could bind to the metals

Oxygen donor

Aspartic acid and glutamic acid

With diagrams, describe the possible binding modes of aspartame and glutamate amino acid residues to metal ions

bind through side chain carboxylate groups

in deprotonated form (carboxylate) - bind the metal ions in two ways;

Chelate; through both O atoms of the carboxylate group to same metal ion

monodentate; through one O atom

e.g - M = Ca - Hard O bind to hard Ca+

Which metal ions are most likely to coordinate the two S containing amino acids

Cysteine & methionine

S = soft donor, requires soft metal e.g. Fe2+, Cu2+, Zn2+