PHARMACOLOGY: DRUG INTERACTIONS

statins and ___________

grapefruit

reduces statin metabolism

muscle pain and aches

antiplatelet drugs and ________

nsaids

risk of bleeding

antiplatelet drugs and______

anticoagulant

risk of bleeding

multivalent ions (calcium, magnesium, iron) (milk and antacids) and _______

levothyroxine

fluoroquinolones

biophosophonates

calcium, magnesium and ___________

bisphosphonate

nitrates and _______

PDE5 inhibtor

causes hypotension

ace inhibitor and _________

potassium-elevating drugs


hyperkalemia

ritonavir and __________

protease inhibitors

metabolizes protease inhibtors

beta blockers and ________

calcium channel blockers


increase risk of heart faliure

bradycardia

broad-spectrum antibiotics and _______

warfarin

increase risk of bleeding

digoxin and _______

digoxin is used for heart failure and arrythmia

loop or thiazide diuretics

increase risk of digoxin toxicity and low potassium

aminoglycosides and ____________

loop diuretics

ototoxicity and kidney damage

antihistamine and ________ (3 drugs)

antihistamines relieve allergies

benzodiazipines

SSRIS

antipsychotic

increase risk of sedation

dont take any of these drugs together because the prolong QT interval

Macrolides
Amiodarone
SSRIs
Fluoroquinolones
Quinine
Antipsychotic drugs
Quinine

corticosteroids and ______

NSAIDS

increase risk of peptic ulceration and GI bleeding

MAO inhibitors and ________

tyramine, fermented food

hyperintensive crisis

omeprazole and _______

clopidogrel

reduces antiplatelet effect

macrolides and _______

statins

inhibit CYP enzymes

increase risk of adverse effects of statins

sulfonylureas and______, dont take any of these drugs together

metformin
sulfonylureas
thiazolidinediones

hypoglycemia

phenytoin and _______ (3 drugs)

warfarins
estrogens
progrestrogens

phenytoin reduce the effects of other drugs

corticosteroids and _______

beta 2-agonists

hypokalemia

alpha- blockers and _______

antihyperintensive


dangerously low blood pressure