malonyl-CoA formation mechanism

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Last updated 6:29 PM on 4/20/26
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6 Terms

1
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step 1:

carbonate oxygen attacks the y-phosphate of ADP.

<p>carbonate oxygen attacks the y-phosphate of ADP.</p>
2
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step 2:

electrons flow out of biotin and into carbonyl phosphate.

<p>electrons flow out of biotin and into carbonyl phosphate.</p>
3
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step 3:

generating carboxybiotin.

<p>generating carboxybiotin.</p>
4
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step 4:

base abstracts proton from alpha carbon, generating enolate.

<p>base abstracts proton from alpha carbon, generating enolate.</p>
5
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step 5:

carboxybiotin decarboxylates.

<p>carboxybiotin decarboxylates.</p>
6
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step 6:

enolate attacks carbon dioxide, generating malonyl-CoA. biotin reprotonates, regenerating enzyme.

<p>enolate attacks carbon dioxide, generating malonyl-CoA. biotin reprotonates, regenerating enzyme.</p>