Dosage + Indication (top)

Atomoxetine

ADHD

40 mg QD

may titrate to 100 mg/d

Benztropine

Extrapyramidal disease:

1-4 mg QD/BID

Parkinsonism:

1-2 mg QD

Buprenorphine/Naloxone

Opioid use disorder:

But: 12-16 mg SL QD

typical dose range from 4 to 24 mg/d

Carbamazepine

Epilepsy, partial, generalized, and mixed types:

200 mg BID

may titrate to 1200 mg po daily

Carbidopa/Levodopa

Parkinson disease: IR: 25 mg/100 mg TID

ER: 50 mg/200 mg BID

-separate doses by at least 6 h;

patients generally treated with 400-1600 mg of levodopa per d;

max 200 mg of carbidopa and 2000 mg of levodopa

Carisoprodol

Disorder of musculoskeletal system

250-350 mg TID and hs

Carvedilol

Heart failure with reduced ejection fraction: 3.125 mg po bid, may titrate to 25 mg po bid for patients weighing <85 kg, 50 mg po bid for patients weighing >85 kg

HTN: 6.25 mg po bid; max 25 mg po bid; ER: 20 mg po am, max 80 mg po daily

Desvenlafaxine

Depression

50 mg QD

Dexmethylphenidate

ADHD, methylphenidate-naive patients:

IR: 2.5 mg BID

max 20 mg/d

ER: 10 mg QD

max 40 mg/d

ADHD, currently using methylphenidate:

one-half the total daily dose of extended-release racemic methylphenidate;

IR: may be switched to the same daily dose of dexmethylphenidate extended release

Eszopiclone

Insomnia:

1 mg immediately before bedtime

Fentanyl Transdermal

Pain, chronic (moderate to severe):

replace patch q72h

-opioid tolerant

-based on the patient’s current 24-h oral morphine requirement

Guanfacine

Attention-deficit hyperactivity disorder (extended release only)

1 mg QD

target dose 1-7 mg/d

HTN

0.5 - 1 mg HS

Ibuprofen

Fever:

200-400 mg q4-6h prn

max 1200 mg/d for OTC use

Pain, headache: 200-400 mg q4-6h prn

max 1200 mg/d for OTC use

Lidocaine

Postherpetic neuralgia and localized pain:

1-3 patches topically simultaneously for up to 12 h within a 24-h period (12 h on, 12 h off)

Lithium

Bipolar disorder, maintenance therapy:

ER: 900-1800 mg/d in 2-3 divided doses

IR: 300 mg po daily

may titrate to 900-1800 mg in 3-4 divided doses

Methadone

Pain, chronic (moderate-severe):

2.5 mg q8h-q12h

-opioid-naive

Drug detoxification, opioid abuse:

15-30 mg q8h (usual range 80-120 mg/d)

Modafinil

Narcolepsy

200 mg QAM

max 400 mg/d

Obstructive sleep apnea, improve excessive sleepiness; adjunct:

200 mg QAM

max 400 mg/d

Shift work-sleep disorder:

200 mg QD 1 h before start of work shift

max 400 mg/d

Naproxen

Osteoarthritis: 250-550 mg BID

Oxcarbazepine

Partial seizure: 300 mg BID

may titrate to 1200-2400 mg/d

Paroxetine

Depression:

IR: 20 mg QD

CR: 25 mg QD

Generalized anxiety disorder: 20 mg QD

Phenobarbital

Epilepsy:

50-100 mg BID/TID

Daytime sedation: 30-120 mg divided into 2-3 doses

Phenytoin

Seizure, generalized tonic-clonic, complex partial, or following neurosurgery, treatment, and prophylaxis:

100-200 mg TID

Pramipexole

Parkinson disease: IR: 0.125-1.5 mg TID

ER: 0.375-4.5 mg QD

Restless leg syndrome:

IR: 0.125-0.5 mg QD 2-3 h prior to bedtime,

Pregabalin

Neuropathic pain, diabetes associated or spinal cord injury associated:

50-100 mg TID

Fibromyalgia

75-150 mg BID

Ropinirole

Parkinson disease: Immediate release, 0.25 mg po tid × 1 wk, then 0.5 mg po tid × 1 wk, then 0.75 mg po tid × 1 wk, then 1 mg po tid, then may titrate to 24 mg/d; extended release, 2 mg po daily × 1-2 wk, then may titrate to 24 mg/d

Restless legs syndrome: the same