Epigenetics, Cancer & Quantitative Genetics

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Last updated 9:01 PM on 4/14/26
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4 Terms

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What is epigenetics?

Heritable changes in gene expression that do NOT involve changes in DNA sequence.

2
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Why was epigenetics discovered?

Identical twins → different phenotypes

X-linked gene expression mismatch

Same genome, different cell types

3
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Euchromatin vs heterochromatin?

Euchromatin:

Open structure

Active transcription

Gene-rich

Heterochromatin:

Condensed

Transcriptionally inactive

Repetitive DNA

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Constitutive vs facultative heterochromatin?

Constitutive: always inactive (centromeres, telomeres)

Facultative: can switch (gene regulation)