Lecture 21: Personalized Treatment of Disease using Cellular Treatments

hematopoietic stem cell transplantation

in bone marrow, peripheral blood, and cord blood

dopaminergic (DA) neurons

degeneration of __ in Parkinson’s Disease

A9 DA neurons

In Parkinson’s disease, which specific group of dopaminergic neurons in the midbrain degenerates?

amyloid plaques, tau tangles

protein buildup in Alzheimer’s disease

multiple sclerosis

immune system attack myelin

reset the immune system

goal of autologous hematopoietic stem cell transplant (HSCT)

paracrine signaling

What do MSCs use to secrete signals that reduce T cell activation and production of inflammatory cytokines in immunomodulation for MS?

Autologous Hematopoietic Stem Cell Transplant (HSCT)

treatment for MS that involves harvesting patient’s own hematopoietic stem cells, going through high-dose chemotherapy, and then re-infusing patient with their own stem cells

immunomodulation using MSCs

treatment for MS that involves MSCs sourced from patient’s bone marrow or adipose tissue

remyelination

treatment for MS using iPS dervied from skin cells to replace damaged oligodendrocytes

retinal pigment epithelial (RPE) cells

cells damaged in Macular Degeneration

limbus zone

zone of tissue that surrounds the iris

CD4

receptor in HIV virus

CCR5

coreceptor in HIV virus

DREAM-HF

trial for heart failure that involves the use of MSCs being injected into patient’s myocardium

chondrocytes

What kind of cells may MSCs develop into to help treat osteoarthritis?