Hardy-Weinberg Analysis

What does HW do

Describes and predicts genotype and allelic frequencies in a non-evolving population

What are the assumptions made for HW

• large populations

• Random mating

• No mutations or mutation equilibrium

• No migration

• No selection

Frequency of A allele

P

Frequency of a allele

Q

2 equations with p / q

P + q = 1

1 - q = p

Hw equation

P² + 2pq + q²

Recessive traits

If the frequency of a recessive trait is known, it is possible to calculate alele frequencies and genotype frequencies using the HW principle

What does an x-linked excessive trait behave like

An autosomal recessive trait

Males who are hemizygous for the x-linked gene will

Be affected because the Y chromosome does not carry a normal allle to compensate for the disease gene

An x-linked recessive disease with gene frequency q will

Be seen in proportion q of males