Biomed 1 - Fracture Repair Stages

Hematoma Formation

Blood vessels that are ruptured during the break swell to form a blood clot. This mass forms between the broken bones. This clotting reduces the blood supply to many of the cells in the area of injury, and as a result, these cells die.

Hematom

Blood clot

Hematoma Formation

Fibrocartilage Callus Formation

New capillaries begin to form into the clotted blood in the damaged area. Connective tissues cells form a mass of repair tissue. This contains some cartilage, some bone, and collagen fibers. The combined mass closes the gap between the broken bones.

Fibrocartilage Callus Formation

Bony Callus Formation

The callus is gradually replaced by one made of spongy bone. Osteoclasts and osteoblasts move to the area and multiply.

Bony callus formation

Bone Remodeling

Over the weeks and months to come, the callus is remodeled with the help of osteoclasts and osteoblasts. The shape of the bones will gradually return to normal, and there will eventually be little evidence of the fracture.

Bone Remodeling

Osteoblasts

Cell that deposits bone tissue

Osteoclasts

Cells with areas of bone resorption that helps with breaking down old or damage tissue

Osteoclasts

Cells that reabsorb bone tissue

Paget’s disease

Increased osteoblast activity compared to osteoclast activity leads to rapidly built bone tissue and weak bones easily fractured

Osteogenesis Imperfecta (OI)

Another name for paget’s disease

Hematoma Formation, Fibrocartilage Callus Formation, Bony Callus Formation, Bone Remodeling

Order of bone remodeling stages