M6: Microbiology, Parasitology, and Public Health - Virology - Part 1 - Introduction

True about virus except:

a. Small infections units

b. Requires electron microscopy to be visialized

c. Obligate intracellular parasite

d. Cannot make energy or proteins independently of the host.

e. None

e. None

Mature viral particle which is the infective form.

a. Prion

b. Virion

c. Capsid

d. Enveloped

e. Plasmid

b. Virion

Viral component:

a. Nucleic acid genome

b. Capsid

c. Envelope

d. a and b

e. b and c

f. All

f. All

True about viral nucleic acid genome except:

a. Can be DNA or RNA

b. Single or double stranded

c. RNA positive sense mimics mRNA

d. RNA negative sense is converted first to mRNA and carry own polymerase

e. None

e. None

Viral RNA that mimics mRNA.

a. Positive sense

b. Negative sense

a. Positive sense

Viral RNA that is converted first to mRNA and carry own polymerase.

a. Positive sense

b. Negative sense

b. Negative sense

Protective protein coat.

a. Nucleic acid genome

b. Capsid

c. Envelope

d. a and b

e. b and c

f. All

b. Capsid

Subunit of capsid.

a. Viriod

b. Virion

c. Capsomere

d. Chromosome

c. Capsomere

Nucleocapsid is composed of:

a. Nucleic acid genome

b. Capsid

c. Envelope

d. a and b

e. b and c

f. All

d. a and b

Nucleic acid genome

Capsid

Nucleocapsid that is 20 equilateral triangles.

a. Icosahedral

b. Helical

c. Complex

a. Icosahedral

Nucleocapsid that is spiral shaped.

a. Icosahedral

b. Helical

c. Complex

b. Helical

Nucleocapsid of a bacteriophage.

a. Icosahedral

b. Helical

c. Complex

c. Complex

Viral phospholipid bilayer which is obtained from host cell membrane as result from budding.

a. Nucleic acid genome

b. Capsid

c. Envelope

d. a and b

e. b and c

f. All

c. Envelope

Viral multiplication cycle:

1- Biosynthesis

2- Assembly

3- Release

4- Attachment

5- Penetration

6- Uncoating

a. 456123

b. 465123

c. 456213

d. 465123

a. 456123

1- Attachment

2- Penetration

3- Uncoating

4- Biosynthesis

5- Assembly

6- Release

Attachment to the target epithelial cell.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

a. Attachment

Engulfment of the virus.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

b. Penetration

Penetration is through endocytosis.

a. Naked virus

b. Enveloped virus

a. Naked virus

Penetration is through fusion of envelope to host membrane.

a. Naked virus

b. Enveloped virus

b. Enveloped virus

Viral content release inside the cell.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

c. Uncoating

Viral RNA entry to the nucleus and replication through RNA polymerase.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

d. Biosynthesis

Phage particles are assembled.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

e. Assembly

Viral particles release to the extracellular fluid.

a. Attachment

b. Penetration

c. Uncoating

d. Biosynthesis

e. Assembly

f. Release

f. Release

Release is through cell lysis.

a. Naked virus

b. Enveloped virus

a. Naked virus

Release is through budding.

a. Naked virus

b. Enveloped virus

b. Enveloped virus

Blocked by:

Amantadine

Rimantadine

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Packaging and assembly

e. Integration

f. Penetration

a. Uncoating

Blocked by:

NRTI

NNRTI

Nucleoside/Nucleotide analogues

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Packaging and assembly

e. Integration

f. Penetration

c. Nucleic acid synthesis

Blocked by "-gravirs".

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Packaging and assembly

e. Integration

f. Penetration

e. Integration - Integrase inhibitors

Blocked by "-navirs".

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Packaging and assembly

e. Integration

f. Penetration

b. Viral protein synthesis - Protease inhibitors

Blocked by "-mivirs".

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Viral release

e. Integration

f. Penetration

d. Viral release - Neuraminidase inhibitors

Blocked by interferon-alfa.

a. Uncoating

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Viral release

e. Integration

f. Penetration

f. Penetration

Blocked by:

Enfuvirtide

Docosanol

Maraviroc

Palivizumab

a. Viral attachment and entry

b. Viral protein synthesis

c. Nucleic acid synthesis

d. Viral release

e. Integration

a. Viral attachment and entry

Smallest infective pathogen known.

a. Viriod

b. Virion

c. Capsid

d. Prion

a. Viriod

Circular ssRNA with composed of nucleic acid only and no protein coating that infects plants.

a. Viriod

b. Virion

c. Capsid

d. Prion

a. Viriod

Smallest human pathogen composed of protein only.

a. Viriod

b. Virion

c. Capsid

d. Prion

d. Prion

Common misfolded brain protein that infects other proteins upon contact.

a. Viriod

b. Virion

c. Capsid

d. Prion

d. Prion

Prion clinical presentation is transmissible spongiform encephalopathy which is degenerative CNS disease resulting to sponge-like brain. This may include the following except:

a. Creutzfeldt-Jakob disease (CJD)

b. Mad cow disease

c. Kuru

d. Scrapie

e. None

e. None

Characteristic of DNA virus.

a. Double stranded

b. Icosahedral

c. Replication site is nucleus

d. a and b

e. b and c

f. All

f. All

The only single stranded DNA virus.

a. Parvovirus

b. Poxviridae

c. Rhabdoviridae

d. Reoviridae

a. Parvovirus

The only complex DNA virus.

a. Parvovirus

b. Poxviridae

c. Rhabdoviridae

d. Reoviridae

b. Poxviridae

The only DNA virus replicated in the cytoplasm.

a. Parvovirus

b. Poxviridae

c. Rhabdoviridae

d. Reoviridae

b. Poxviridae

DNA Virus:

I. Parvoviridae

II. Papillomaviridae

III. Polyomaviridae

IV. Adenoviridae

V. Herpesviridae

VI. Hepadnaviridae

VII. Poxviridae

a. I, II, III, IV, V, VI, VII

b. I, II, III, IV

c. V, VI, VII

d. I, II, III

e. IV, V, VI, VII

a. I, II, III, IV, V, VI, VII

"Pardon PaPa As He Has Pox"

Naked DNA Virus:

I. Parvoviridae

II. Papillomaviridae

III. Polyomaviridae

IV. Adenoviridae

V. Herpesviridae

VI. Hepadnaviridae

VII. Poxviridae

a. I, II, III, IV, V, VI, VII

b. I, II, III, IV

c. V, VI, VII

d. I, II, III

e. IV, V, VI, VII

b. I, II, III, IV

Naked DNA Virus:

• Parvoviridae

• Papillomaviridae

• Polyomaviridae

• Adenoviridae

Enveloped DNA Virus:

I. Parvoviridae

II. Papillomaviridae

III. Polyomaviridae

IV. Adenoviridae

V. Herpesviridae

VI. Hepadnaviridae

VII. Poxviridae

a. I, II, III, IV, V, VI, VII

b. I, II, III, IV

c. V, VI, VII

d. I, II, III

e. IV, V, VI, VII

c. V, VI, VII

Enveloped DNA Virus:

• Herpesviridae

• Hepadnaviridae

• Poxviridae

RNA virus general characteristics except:

a. Helical

b. Enveloped

c. Cytoplasmic replication

d. Single stranded

e. None

e. None

Only bullet shaped RNA virus.

a. Rhabdoviridae

b. Picornaviridae

c. Retroviridae

d. Reoviridae

a. Rhabdoviridae

Only double stranded RNA virus.

a. Rhabdoviridae

b. Picornaviridae

c. Retroviridae

d. Reoviridae

d. Reoviridae

Only naked RNA virus.

a. Picornavirus

b. Reovirus

c. Calicivirus

d. a and b

e. b and c

f. All

f. All

Naghubad sa "PRC" - Naked RNA Virus:

• Picornavirus

• Reovirus

• Calicivirus

Only RNA virus replicated in the nucleus.

a. Retrovirus

b. Orthomyxovirus

c. Influenza virus

d. a and b

e. b and c

f. All

f. All

Nucleus replicated virus:

• Reovirus

• Orthomyxovirus

• Influenza virus

Positive sense RNA virus:

I. Picornavirus

II. Coronavirus

III. Togavirus

IV. Calicivirus

V. Flavivirus

VI. Retrovirus

VI. Reovirus

a. I, II, III, IV, V, VI, VII

b. I, II, III, IV, V, VI

c. I, II, III, IV, V

d. I, II, III

e. IV, V, VI, VII

a. I, II, III, IV, V, VI, VII

Positive sense RNA virus: "PiCoTCaFlaRe"

• Picornavirus

• Coronavirus

• Togavirus

• Calicivirus

• Flavivirus

• Retrovirus

• Reovirus

Negative sense RNA virus:

I. Paramyxovirus

II. Filovirus

III. Arenavirus

IV. Bunyavirus

V. Orthomyxovirus

VI. Rhabdovirus

a. I, II, III, IV, V, VI

b. I, II, III, IV, V

c. I, II, III, IV

d. I, II, III

e. IV, V, VI

a. I, II, III, IV, V, VI

Negative sense RNA virus: "ParFABOR"

• Paramyxovirus

• Filovirus

• Arenavirus

• Bunyavirus

• Orthomyxovirus

• Rhabdovirus