Extracellular Deposition and Amyloidosis

These flashcards encompass key vocabulary and definitions related to extracellular deposition and amyloidosis discussed during the lecture.

Extracellular Deposition

An abnormal element deposited around cells.

Hyalinosis

An alteration giving a homogenous, acellular glassy pink appearance in H&E stained sections.

Pathological Calcification

Abnormal deposition of calcium salts in injured or dead tissue.

Dystrophic Calcification

Normal calcium metabolism with deposition in damaged tissues.

Metastatic Calcification

Occurs in normal tissues due to hypercalcemia, often linked to parathyroid hormone excess.

Amyloidosis

A disorder characterized by extracellular deposition of various fibrillary proteins in organs.

AL Amyloid

Amyloid light chain composed of complete immunoglobulin light chains.

AA Amyloid

Derived from serum amyloid associated protein, commonly seen in chronic inflammatory conditions.

Fibrillary Proteins

Proteins that aggregate and misfold, leading to amyloid formation.

Macrophages

Cells that play an important role in amyloidosis by processing precursor proteins into amyloid fibrils.

Amyloid Fibrils

Protein aggregates that are deposited in various tissues and lead to functional impairment.

Sago Spleen

A type of splenic amyloidosis characterized by focal deposition in lymphoid follicles.

Reactive Systemic Amyloidosis

Amyloidosis caused by chronic inflammation, often tied to diseases like rheumatoid arthritis.

Hemodialysis-Associated Amyloidosis

Amyloidosis in patients undergoing long-term dialysis due to β2 microglobulin deposits.

Endocrine Amyloid

Amyloid associated with certain endocrine tumors, typically producing procalcitonin.

Clinical Features of Amyloidosis

Nonspecific symptoms such as weakness, weight loss, and complications related to organ involvement.

Prognosis of Amyloidosis

Generalized amyloidosis has a poor prognosis; management of underlying conditions can improve outcomes.

Morphology in AA Amyloidosis

Amyloid deposits often found in kidneys, liver, spleen, and adrenal glands.

Morphology in AL Amyloidosis

Amyloid deposits primarily affect the heart, gastrointestinal and respiratory tracts.