Nonsteroidal Antiasthma Agents

Flashcards for Nonsteroidal Antiasthma Agents

Cromolyn-like drugs

Mast cell stabilizers used as nonsteroidal antiasthma agents.

Antileukotrienes

A subgroup of nonsteroidal antiasthma agents.

Monoclonal antibodies

A subgroup of nonsteroidal antiasthma agents used in asthma treatment.

Cromolyn and Anti-LT

Alternatives to ICS in asthma requiring step 2 care.

Cromolyn

Often used with infants and young children as alternatives to ICS in asthma requiring step 2 care because of safety profiles of ICS.

Antileukotrienes

Can be useful in combination with ICS to reduce the steroid dose.

Cromolyn-Like Agents (Mast Cell Stabilizers)

Generic only

Zafirlukast

Accolate

Montelukast

Singulair

Zileuton

Zyflo; Zyflo CR

Omalizumab

Xolair

Benralizumab

Faserna

Mepolizumab

Nucala

Relizumab

Cinqair

Extrinsic asthma

Depends on allergy, atopy

Intrinsic asthma

Shows no evidence of sensitization to common inhaled allergens

Leukotrienes

Released by mast cells; Examples are Leukotrienes, Prostaglandins, Proteases, Histamines, Platelet-activating factor (PAF), Cytokines.

Cromolyn sodium (disodium cromoglycate)

SVN 20 mg/ampule or 20mg/2mL (1%)

Cromolyn

Prevents mast cell degranulation

Leukotrienes

Potent bronchoconstrictors that stimulate airway edema, mucus secretion, ciliary beat inhibition, and recruitment of other inflammatory cells.

Zileuton

An inhibitor of the 5-LO enzyme pathway.

Zafirlukast

Leukotriene receptor antagonist.

Montelukast

Leukotriene receptor antagonist that binds with high affinity and selectivity to CysLT1 receptor subtype.

Antileukotriene Agents

Prophylactic controller drugs used in persistent asthma and an alternative to inhaled corticosteroids or cromolyn-like agents.

Omalizumab

Blocks the attachment of IgE to mast cells reducing inflammatory mediators.

Benralizumab, mepolizumab and reslizumab

Block interleukin-5 (IL-5) in treating eosinophilic asthma.