CARCINOMA OF STOMACH

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Last updated 2:34 PM on 4/12/26
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4 Terms

1
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aetiopathogenesis

  1. environmental factor

  • diet

-nitrite derived from nitrate

-smoked and salted food

-lack of fresh fruit and vegetable

  • low socio-economic status

  • cigarette smoking

  1. host factors

  • chronic gastritis dt H.pylori

  • autoimmune gastritis

  • partial gastrectomy

  • gastric adenomas

  • barret esophagus

  • atrophic gastritis

  1. genettic factor

  • inc risk with blood gp A

  • family history of gastric cancer

  • hereditary non polyposis colon cancer syndrome

  • familial gastric carcinoma (E-cadherin mutation)

2
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modes of transmission

  1. Virchow (sentinel) node→ left supraclavicular node

  2. Sister Joseph Mary nodule→ subciutaneous nodule in periumbilical node

  3. Krukenberg tumor→ spread to ovary

  4. Paraneoplastic skin lesion → Acanthosis nigricans

3
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gross

  1. location

  • cardia of stomach

  • body and fundus

  • pylorus and antrum

  1. flat, polypoid and excavated lesion

  2. ulcer >3cm, heaped up margin, necrotic ulcer base

4
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histologically

  1. intestinal type

  • gland forming adenocarcinoma

  1. diffuse type

  • not related to H.pylori

  • diffuse infiltration of stomach by poorly differentiated tumor cells

  • Signet ring cells

  • nucleus is displaced to periphery by intracellular mucin