HEART AND VASCULAR SYSTEM (1)

Chemotherapy agents (e.g. Doxorubicin)

The generation of reactive oxygen species leads to oxidative stress and mitochondrial dysfunction, which can result in myocardial damage and heart failure.

Cocaine
Methamphetamine

Inhibition of norepinephrine and dopamine reuptake leads to increased sympathetic activity and vasoconstriction, which can cause hypertension, arrhythmias, and myocardial ischemia.

Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g. Ibuprofen)

Inhibition of cyclooxygenase enzymes can result in decreased prostaglandin synthesis, leading to vasoconstriction and increased risk of hypertension, myocardial infarction, and stroke

Tricyclic antidepressants (e.g. Amitriptyline)

Blockade of norepinephrine and serotonin reuptake, leading to increased sympathetic activity and vasoconstriction, which can cause hypertension, arrhythmias, and myocardial ischemia.

Statins (e.g. Atorvastatin)

Inhibition of HMG-CoA reductase, resulting in decreased cholesterol synthesis, which can lead to improved endothelial function, but in rare cases, can cause myopathy and rhabdomyolysis.

Antipsychotics (e.g. Haloperidol)

Blockade of dopamine receptors, leads to increased sympathetic activity and vasoconstriction, which can cause hypertension, arrhythmias, and myocardial ischemia.