NURS 225: antineoplastic drugs (mitotic inhibitors, alkaloid ii inhibitors, topomerase inhibitors, enzymes)
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12 Terms
what is the mechanism of action for mitotic inhibitors?
work shortly before or during mitosis and cause slow cell division
what are the indications for mitotic inhibitors?
treats a variety of solid tumors and some hematologic malignancies
what are the adverse effects of mitotic inhibitors?
hair loss, nv, myelosuppression. liver, kidney, and lung toxicities. convulsions. extravasation
what is the mechanism of action of alkaloid topoisomerase ii inhibitors?
inhibit the enzyme topoisomerase ii, which causes a break in dna strands
what are the indications for alkaloid topoisomerase ii inhibitors?
small cell lung cancer and testicular cancer
what are the indications for topoisomerase i inhibitors?
ovarian, colorectal, and small cell lung cancer
what is the mechanism of action of topoisomerase i inhibitors?
prevent dna relegation, thus causing the dna strand to break
what are the topoisomerase i inhibitor drugs?
topotecan and irinotecan
what are the adverse effects of topotecan?
bone marrow suppression, nv, diarrhea, vomiting, headache, rash, muscle weakness, cough
what are the adverse effects of irinotecan?
hematologic, cholinergic diarrhea, nv
what is the indication for antineoplastic enzymes?
acute lymphocytic leukemia
what are the adverse effects of antineoplastic enzymes?
impaired pancreatic function which can lead to hyperglycemia