2.GENERAL PHYSIOLOGY OF THE NERVOUS SYSTEM

1. Reflexes are defined as motor, vasomotor and secretoryaccording to:

a) the location of the receptors;

b) the type of the effector;

c) the mechanism of their formation;

d) the type of reflex arc;

e) the complexity of the reflex are .

b) the type of the effector

2. Irradiation of the excitation in the nervous system is achieved by:

a) release of comediators;

b) increased velocity of conduction in neurons;

c) inhibition;

d) divergence;

e) convergence.

d) divergence

3. Conditioned reflexes are:

a) inborn;

b) permanent;

c) individual;

d) the same in every human;

e) have constant reflex arch.

c) individual

4. What is the interactionbetween two inhibitory neurons known as?

a) recurrent inhibition;

b) disinhibition;

c) presynaptic inhibition;

d) lateral inhibition;

e) reciprocal inhibition.

b) disinhibition;

5. In which sensory system is lateral inhibition used?

a) auditory system;

b) tactile system;

c) olfactorysystem;

d) gustatorysystem.

e) visual system;

e) visual system;

6. Abdominal wall rigidity reflex is:

a) baroreceptive reflex;

b) somato-somatic;

c) viscero-somatic;

d) viscero-visceral;

e) somato-visceral.

c) viscero-somatic

7. Which glial cells help regulate extracellular K+ levels in the CNS??

a) microcytes;

b) astrocytes;

c) oligodendrocytes;

d) Schwanncells;

e) ependymal cells.

b) astrocytes

8. a-adrenoreceptors:

a) are located in the bronchi and bronchioles;

b) are distinguishable from ß (beta) receptors using electron microscopy;

c) are involved in the vasodilation responsesto adrenaline in skin;

d) can be stimulatedby both adrenaline and noradrenaline;

e) are involved in heart rate responses to noradrenaline.

d) can be stimulatedby both adrenaline and noradrenaline;

9. Which one of the following is characteristic of type A nerve fibers:

a) nociception only;

b) slower conduction than C fibers;

c) motor only;

d) myelinated;

e) sensoryonly.

d) myelinated

10. The unique property of the neuron is:

a) communication;

b) contraction;

c) secretion;

d) energy production;

e) excitation.

a) communication;

11. The electroencephalogram(EEG)registers the activity of the:

a) reticular activating system;

b) cortex;

c) limbic system;

d) thalamus;

e) brainstem.

b) cortex;

1 2 . The medulla oblongata doesnot regulate which of the following:

a) breathing;

b) heart function;

c) body temperature;

d) vomiting;

e) sneezing.

c) body temperature;

13. What anatomical region of a multipolar neuron has the lowest threshold for generating an action potential?

a) soma;

b) distal axon;

c) dendrites;

d) axon hillock;

e) proximal axon.

d) axon hillock;

14. The action potential of a nerve cell:

a) results from a large increase in membrane permeability to Na+ ions;

b) can summate with one another;

c) may vary considerably in amplitude;

d) become larger as stimulus strength increases;

e) follows from a decrease in membrane permeability for K+ ions.

a) results from a large increase in membrane permeability to Na+ ions;

15. Prevertebral sympathetic ganglia are involved with the innervation of the:

a) abdominal organs;

b) thoracic organs;

c) head;

d) hair erector muscles;

e) skeletal muscles.

a) abdominal organs;

16. Excitationinthe nervous systemissummed up by:

a) release of comediators;

b) increased velocityofconductionin neurons;

c) inhibition;

d) divergence;

e) convergence

e) convergence

17. A reflex action:

a) is initiated by sensory receptors;

b) always results in endocrine secretion;

c) involves transmission across at least two central nervous synapses series,

d) is always inhibitory;

e) is independent of higher centres in the brain.

a) is initiated by sensory receptors;

18. At the neuromuscular junction:

a) the muscle membrane possesses muscarinic receptors;

b) the motor nerve endings secrete norepinephrine (noradrenalin);

c) curare leads to prolongation of neuromuscular transmission;

d) the motor nerve endings secrete acetylcholine;

e) none of the answers are correct.

d) the motor nerve endings secrete acetylcholine;

19. The cerebrospinal fluid:

a) protects the brain from injury when the head is moved.

b) is formed in the arachnoid granulations.

c) provides the brain with most of its nutrition.

d) has a lower pressure than that in the cerebral venous sinuses.

e) flows around the adult brain and is around 5 litres per day.

a) protects the brain from injury when the head is moved.

20. An excitatory post-synaptic potential:

a) is the depolarization of a post-synaptic nerve cell membrane that occurs when a presynaptic neurone is stimulated;

b) involves reversal of polarity across the post-synaptic nerve cell membrane;

c) may be recorded from a posterior root ganglion cell;

d)is propagated at the samerate as an action potential;

e) is caused by the electrical field induced by activity in the pre-synaptic nerve terminals.

a) is the depolarization of a post-synaptic nerve cell membrane that occurs when a presynaptic neurone is stimulated;

21. Where is the receptor located in exteroreceptive reflexes?

a) tendons and muscles;

b) joints;

c) blood vessels;

d) skin and mucosa;

e) visceral organs.

d) skin and mucosa;

22.During deep sleep there is a fallin:

a) skin temperature of the hand;

b) metabolic rate;

c) arterial pCO2;

d) blood growth hormone/cortisol ratio;

e) ph.

b) metabolic rate;

23. Sympathetic:

a) ganglionic transmission mediated by acetylcholine;

b) neuromuscular transmissionin is in the heart is mediated by acetylcholine

c) neuromuscular transmission in the arterioles of the hand is mediated by acetylcholine,

d) neuroglandular transmission in sweat glands is mediated by noradrenaline;

e) neuromuscular transmission in the iris is mediated by

acetylcholine

a) ganglionic transmission mediated by acetylcholine;

24. Select the excitatory neurotransmitter:

a) GABA;

b) glutamate;

c) glycine;

d) serotonin;

e) dopamine.

b) glutamate;

25. The blood-brain barrier:

a) slows equilibration of solutes between blood and brain

tissue fluids;

b) is a more effective barrier for fat-soluble substances than water-soluble substances;

c)is am ore effective barrier in infants than in adult;

d) is a more effective barrier for CO2 than for 02;

e) permits hydrogen io n s to pass freely.

a) slows equilibration of solutes between blood and brain

tissue fluids;

26. Most axons are covered by a fatty sheath called:

a) myelin;

b) neurilema;

c) the nodes of Ranvier;

d) neural adipose;

e) sarcolema.

a) myelin;

27. The electroencephalogram normally shows voltage wave :

a) whose amplitude is relatedto intelligence;

b) of lower frequency during deep sleep than during alert

wakefulness;

c) of smaller amplitude during deep sleep than during alert wakefulness,

d) of greater amplitude than those of the electrocardiogram;

e ) which are bilaterally unsymmetrical.

b) of lower frequency during deep sleep than during alert

wakefulness;

28. Which are the most important EEG waves during wakefulness with opened eyes:

a) gamma(y);

b) alpha(a);

c) beta(ß);

d) delta (S);

e) alpha (a) and delta (S).

c) beta(ß);

29. Parasympathetic nerves:

a) have no effect on lacrimation;

b) cause vasodilatation in skeletal muscle during prolonged exercise;

c) have effects on intestinal smooth muscles opposite to sympathetic nerves;

d) cause sweat secretion in skin when bodytemperature rises;

e) have longer postganglionic than preganglionic fibres.

c) have effects on intestinal smooth muscles opposite to sympathetic nerves;

30. The a (alpha) rhythm of the electroencephalogram:

a) disappearswhen the eyes areclosed;

b) is an electrical potential with man amplitude around one millivolt;

c) has a frequency of 8-12 Hz;

d) has a lower frequency than the S (delta) rhythm;

e) indicates that the subject is sleeping.

c) has a frequency of 8-12 Hz;

31. Laws of transmission in chemical synapses do not include:

a) one-way conduction;

b) amplitude coding in the postsynaptic membrane;

c) delayedtransmission;

d) two-way conduction;

e) summation.

d) two-way conduction;

32 . Generalized parasympathetic activity is characterized by:

a) contraction of the radial muscle in the iris;

b) increased secretionof catecholamines;

c ) increased activity of digestive system;

d) lipolysis in adipose tissue;

e) increased conduction rate in the atrio-ventricular bundle.

c ) increased activity of digestive system;

33. Acetylcholine:

a) acts on the same type of receptor on postganglionic fibres in sympathetic and parasympathetic ganglia;

b)acts on the different type of receptor on target organs at cholinergic sympathetic and parasympathetic nerve terminals;

c) acts on the same type of receptor at autonomic ganglia and at somatic neuromuscular junctions;

d) acts on alpha and beta receptors;

e) in blood is hydrolyzed by the same cholinesterase as is found at neuromuscular junctions.

a) acts on the same type of receptor on postganglionic fibres in sympathetic and parasympathetic ganglia;

34. Sensory neurons have:

a) a short dendrite and a long axon;

b) a short dendrite and a short axon;

c) a long dendrite and a short axon;

d)along dendrite and along axon;

e) their axons and dendrites may be either long or short.

c) a long dendrite and a short axon;

35. An inhibitory postsynaptic potential:

a) may be recordedin a postganglionic sympathetic neurone;

b)maybe recorded in an axon:

c) does not exceed one millivolt in amplitude;

d) moves membrane potential towards the equilibrium potential for sodium;

e) may summate in space and time with other excitatory and

inhibitory potentials in the same neurone.

e) may summate in space and time with other excitatory and

inhibitory potentials in the same neurone.

36. A volley of impulses travelling in a presynaptic neurone causes:

a) an identical volley in the postsynaptic neurone.

b) summation of action potentials; terminals

c) an increase in the permeability of the presynaptic nerve

to calcium;

d) the generation of at least one action potential in the postsynaptic neurone;

e) endocytosis of neurotransmitter.

c) an increase in the permeability of the presynaptic nerve

to calcium;

37. Pain receptors are:

a) similar in structure to Pacinian corpuscles;

b) stimulated by a rise in the local K+ concentration;

c) quick to adapt to a constant stimulus

d) more easily stimulatedin intactthan in injuredtissue;

e) stimulatedin the wallof the gutbyagents which damagethe

constant stimulus;

b) stimulated by a rise in the local K+ concentration;

38.Rapid eye movement (REM) sleep differs from non-REM sleepin that:

a)the EEG shows waves of higher frequency;

b) muscle tone is higher;

c) heart rate and respiration are more regular;

d) secretionof growth hormoneis increased;

e) blood pressure is decreased.

a)the EEG shows waves of higher frequency;

39. Where is the receptor locatedin proprioreceptive reflexes?

a) joints, tendons and muscles;

b) serous cavities;

c) blood vessels;

d) skin and mucosa;

e) visceral organs.

a) joints, tendons and muscles;

40. Excessive formation of a substance/secretion in the body is controlled in order to maintain homeostasis by:

a) positive feedback mechanism;

b) negative feedback mechanism;

c) osmosis;

d) haemodynamics;

e) up-regulation.

b) negative feedback mechanism;

41. Delta (S) wave activity in the electroencephalogram:

a) is low in frequency and amplitude;

b) suggests that the patient is alert and concentrating;

c) suggests that t h e patient is with opened eyes;

d) is a feature of petit mal epilepsy;

e) is more common in children than in adults while they are awake.

e) is more common in children than in adults while they are awake.

42. In which glial cells is the enzyme carbonic anhydrase found?

a) microcytes;

b) oligodendrocytes;

c) Schwann cells;

d) astrocytes;

e) ependymal cells.

d) astrocytes;

43. The sympathetic response to stress includes:

a) increased blood pressure and increased glycogen breakdown in liver and muscles;

b) decreased glycogen breakdown in liver and muscles;

c) increased glycogen synthesis in liver and muscles;

d) decreased blood clotting;

e) decrease of the respiratoryrate.

a) increased blood pressure and increased glycogen breakdown in liver and muscles;

44. Atropine causes:

a) paralysis ofaccommodation for near vision in the eye;

b) constriction of the pupil;

c) constriction of the bronchi;

d) diarrhoea;

e) bradycardia.

a) paralysis ofaccommodation for near vision in the eye

45. Blockade of parasympathetic activity causes a reduction in:

a) sweat production;

b) resting heart rate;

c) blood pressure;

d) the strength of skeletal muscle contraction;

e) salivation.

e) salivation.

46. Blockade of ß-adrenoceptors is not likely to cause:

a) disturbancein renal-angiotensin-aldosteronesystem;

b) impaired relaxation of the smooth musclesin the digestive

system;

c) worsening of the conditionin patients with bronchial asthma;

d) worsening of the condition in patients in cardiac failure;

e) inability toincrease heartrate during exercisein patients with transplantedhearts.

b) impaired relaxation of the smooth musclesin the digestive

system;

47. What is transported by retrograde axonal transport?

a) products of the mediators degradation;

b) mediators;

c) structural proteins;

d) modulators;

e) nucleic acids.

a) products of the mediators degradation;

48. All of these characteristics belong to postsynaptic potentials, except for:

a) there are no refractory periods;

b) they have constant magnitude;

c) summation is possible;

d) typically occur at the cell body of a neuron;

e) they are decremental.

b) they have constant magnitude;

49. Compared with the endocrine system, regulation of the body by the nervous system provides:

a) relatively slow butlong-lasting responses to stimuli;

b) swift but brief responses to stimuli;

c) swift, long-lasting responses to stimuli;

d) antagonist hormone interactions;

e) relatively slow, short-lived responses to stimuli.

b) swift but brief responses to stimuli;

50. Which of these characteristics is not relatedtothe parasympathetic division of the ANS?

a) urination;

b) defecation;

c) sweating;

d) salivation;

e) lacrimatio

c) sweating;

51. W hich of the following has slowest conduction:

a) A (alpha) fibers;

b) A (beta) fibers;

c) A (gamma)fibers;

d) B fibres;

e) C fibres.

e) C fibres

52. Saltatory conduction:

a) is seen only in myelinated nerve fibres;

b) is slower that non saltatory conduction;

c) is not affected if a local anesthetic is applied to the nodes of Ranvier;

d) is seen only in sensory fibers;

e) is seen only in the cortex.

a) is seen only in myelinated nerve fibres;

53. Myelin sheath is produced by:

a) axoplasm;

b) mitochondria;

c) Schwann cell;

d) muscle cell;

e) endocrine cell.

c) Schwann cell;

54. The morphological substarte of thefast anterograde axonal transport is:

a) myofilaments;

b) microtubules;

c) ribosomes;

d) sarcoplasmic reticulum;

e) ion channels.

b) microtubules;

55.Sleep is associated with:

a) an alpha rhythm in the electroencephalogram;

b) increased activity in the reticular activating system.

c) a beta rhythm in the EEG;

d) a high level of vagal tone to the heart and grinding movements of the teeth;

e) a rise in central body temperature.

d) a high level of vagal tone to the heart and grinding movements of the teeth;

56. From childhood to old age:

a) there is a steady increase into total sleeping time per day;

b) deep (stage4) sleep increases as a percentage of total daily sleep;

c) body water as a percentage of body mass increases;

d) sleep becomes less aggregated into as single sleeping period.

e) basal metabolic rateincreases.

d) sleep becomes less aggregated into as single sleeping period

57. The sympathetic preganglionic neurons of the ANS secrete:

a) dopamine;

b) acetylcholine;

c) adrenaline;

d) serotonin;

e) histamine.

b) acetylcholine;

58.The adrenergic effect on the motor activity of the digestive system is:

a) to cause mixing movements;

b) to cause peristalsis;

c) to inhibit the motor activity;

d) to cause mass movements;

e) is dose dependent.

c) to inhibit the motor activity;

59. Reflexes are defined as somatic, visceral and mixed:

a) according to the location ofthe receptors;

b) according to the type of the reflex arc;

c) according to the effectors;

d) according to the location of the interneurons;

e) according to formation.

b) according to the type of the reflex arc;

60. The adrenal medulla is innervated by:

a) preganglionic cholinergic neurons;

b) postganglionic cholinergic neurons;

c) preganglionic adrenergic neurons;

d) postganglionic adrenergic neurons;

e) preganglionic dopaminergic neurons.

a) preganglionic cholinergic neurons;

61. The increased tone of the parasympathetic division leads to :

a) contraction of the pupils and bronchial smooth muscle fibers;

b)dilation of the pupils and relaxation of the bronchial smooth muscle

c) contraction of the pupils and relaxation of the bronchial smooth muscle

d) dilation of the pupils and contraction of the bronchial smooth muscle fibers

e) dilation of the pupils and no effect on the bronchial smooth muscle fibers

a) contraction of the pupils and bronchial smooth muscle fibers;

62. The main structural and functional unit in the nervous system system is:

a) axon;

b) dendrites;

c) neuron;

d) brain nucleus;

e) neural network.

c) neuron;

63. The bodies of sensory neurons are located:

a) in the anterior horns of the spinal cord;

b) in theanteriorhoms ofthe spinal cord andthe nuclei of cranial nerves;

c) in the dorsal root ganglia of the spinal cord;

d) in the cerebral cortex;

e) outside the CNS.

c) in the dorsal root ganglia of the spinal cord;

64. Glial tissue:

a) participates in the processing of information;

b) participates in the transmission of information;

c) participates in the storage of information;

d) participates in the reception of information;

e) has a metabolic and supporting function.

e) has a metabolic and supporting function.

65. What is the name of the set of neuronsin the CNS required for theoccurance of a certain reflex:

a) reflex arc;

b) motor unit;

c) receptive field;

d) nerve center;

e) effectors.

d) nerve center;

66.Reflexes are devidedinto mono- and polysynaptic according to:

a) the location of the receptors;

b) the type of effector;

c) the mechanism of their formation;

d) the type of reflex arc;

e) the complexity of the reflex arc.

e) the complexity of the reflex arc.

67. Reflexes are classified as conditioned and unconditioned according to:

a) the location of the receptors;

b) the type of effector;

c) the mechanism of their formation;

d) the location of the nerve center;

e) the complexity of the reflex arc.

c) the mechanism of their formation;

68. Which ofthe following glialcellsare related to the formation of the blood- brain barrier?

a) microcytes;

b) oligodendrocytes;

c) Schwanncells;

d) astrocytes;

e) ependymal cells.

d) astrocytes;

69. Which of the glial cells perform phagocytosis?

a) microcytes and oligodendrocytes;

b) oligodendrocytesandprotoplasmicastrocytes;

c) reactive astrocytes and fibrous astrocytes;

d) microcytes and reactive astrocytes;

e) microcytes and fibrous astrocytes.

d) microcytes and reactive astrocytes;