2.3: Coagulation System Disorders

The APTT is sensitive to a deficiency of which clotting factor?

A. Factor VII

B. Factor X

C. PF3

D. Calcium

The APTT is sensitive to a deficiency of which clotting factor?

A. Factor VII

B. Factor X

C. PF3

D. Calcium

Which test result would be normal in a patient with dysfibrinogenemia?

A. TT

B. APTT

C. PT

D. Immunologic fibrinogen level

Which test result would be normal in a patient with dysfibrinogenemia?

A. TT

B. APTT

C. PT

D. Immunologic fibrinogen level

A patient with a prolonged PT is given intravenous vitamin K. PT is corrected to normal after 24 hours. Which clinical condition most likely caused these results?

A. Necrotic liver disease

B. Factor X deficiency

C. Fibrinogen deficiency

D. Obstructive jaundice

A patient with a prolonged PT is given intravenous vitamin K. PT is corrected to normal after 24 hours. Which clinical condition most likely caused these results?

A. Necrotic liver disease

B. Factor X deficiency

C. Fibrinogen deficiency

D. Obstructive jaundice

Which factor deficiency is associated with prolonged PT and APTT?

A. Factor X

B. Factor VIII

C. Factor IX

D. Factor XI

Which factor deficiency is associated with prolonged PT and APTT?

A. Factor X

B. Factor VIII

C. Factor IX

D. Factor XI

Prolonged APTT is corrected with factor VIII–deficient plasma but not with factor IX deficient plasma. Which factor is deficient?

A. Factor V

B. Factor VIII

C. Factor IX

D. Factor X

Prolonged APTT is corrected with factor VIII–deficient plasma but not with factor IX deficient plasma. Which factor is deficient?

A. Factor V

B. Factor VIII

C. Factor IX

D. Factor X

Which of the following is a characteristic of classic hemophilia A?

A. Abnormal PLT aggregation

B. Autosomal recessive inheritance

C. Mild to severe bleeding episodes

D. Prolonged PT

Which of the following is a characteristic of classic hemophilia A?

A. Abnormal PLT aggregation

B. Autosomal recessive inheritance

C. Mild to severe bleeding episodes

D. Prolonged PT

Refer to the following results:

PT = prolonged

APTT = prolonged

PLT count = decreased

Which disorder may be indicated?

A. Factor VIII deficiency

B. von Willebrand disease

C. DIC

D. Factor IX deficiency

Refer to the following results:

PT = prolonged

APTT = prolonged

PLT count = decreased

Which disorder may be indicated?

A. Factor VIII deficiency

B. von Willebrand disease

C. DIC

D. Factor IX deficiency

Which of the following is a predisposing condition for the development of DIC?

A. Adenocarcinoma

B. Idiopathic thrombocytopenic purpura (ITP)

C. Post transfusion purpura (PTP)

D. Heparin-induced thrombocytopenia (HIT)

Which of the following is a predisposing condition for the development of DIC?

A. Adenocarcinoma

B. Idiopathic thrombocytopenic purpura (ITP)

C. Post transfusion purpura (PTP)

D. Heparin-induced thrombocytopenia (HIT)

Factor XII deficiency is associated with:

A. Bleeding episodes

B. Epistaxis

C. Decreased risk of thrombosis

D. Increased risk of thrombosis

Factor XII deficiency is associated with:

A. Bleeding episodes

B. Epistaxis

C. Decreased risk of thrombosis

D. Increased risk of thrombosis

The following results were obtained on a patient: normal PLT count and function, normal PT, and prolonged APTT. Which of the following disorders is most consistent with these results? A. Hemophilia A

B. Bernard–Soulier syndrome

C. von Willebrand disease

D. Glanzmann thrombasthenia

The following results were obtained on a patient: normal PLT count and function, normal PT, and prolonged APTT. Which of the following disorders is most consistent with these results? A. Hemophilia A

B. Bernard–Soulier syndrome

C. von Willebrand disease

D. Glanzmann thrombasthenia

The following laboratory results were obtained from a 40-year-old woman: PT = 20 sec; APTT = 50 sec; TT = 18 sec. What is the most probable diagnosis?

A. Factor VII deficiency

B. Factor VIII deficiency

C. Factor X deficiency

D. Hypofibrinogenemia

The following laboratory results were obtained from a 40-year-old woman: PT = 20 sec; APTT = 50 sec; TT = 18 sec. What is the most probable diagnosis?

A. Factor VII deficiency

B. Factor VIII deficiency

C. Factor X deficiency

D. Hypofibrinogenemia

When performing a factor VIII activity assay, a patient’s plasma is mixed with:

A. Normal patient plasma

B. Factor VIII–deficient plasma

C. Plasma with a high concentration of factor VIII

D. Normal control plasma

When performing a factor VIII activity assay, a patient’s plasma is mixed with:

A. Normal patient plasma

B. Factor VIII–deficient plasma

C. Plasma with a high concentration of factor VIII

D. Normal control plasma

The most suitable product for treatment of factor VIII deficiency is:

A. Fresh frozen plasma (FFP)

B. Factor VIII concentrate

C. Prothrombin complex concentrate

D. Factor V Leiden

The most suitable product for treatment of factor VIII deficiency is:

A. Fresh frozen plasma (FFP)

B. Factor VIII concentrate

C. Prothrombin complex concentrate

D. Factor V Leiden

Which of the following is associated with an abnormal PLT aggregation test result?

A. Factor VIII deficiency

B. Factor VIII inhibitor

C. Lupus anticoagulant

D. Afibrinogenemia

Which of the following is associated with an abnormal PLT aggregation test result?

A. Factor VIII deficiency

B. Factor VIII inhibitor

C. Lupus anticoagulant

D. Afibrinogenemia

Refer to the following results:

PT = normal

APTT = prolonged

PLT count = normal

PLT aggregation to ristocetin = abnormal

Which of the following disorders may be indicated?

A. Factor VIII deficiency

B. DIC

C. von Willebrand disease

D. Factor IX deficiency

Refer to the following results:

PT = normal

APTT = prolonged

PLT count = normal

PLT aggregation to ristocetin = abnormal

Which of the following disorders may be indicated?

A. Factor VIII deficiency

B. DIC

C. von Willebrand disease

D. Factor IX deficiency

Which results are associated with hemophilia A?

A. Prolonged APTT, normal PT

B. Prolonged PT and APTT

C. Prolonged PT, normal APTT

D. Normal PT and APTT

Which results are associated with hemophilia A?

A. Prolonged APTT, normal PT

B. Prolonged PT and APTT

C. Prolonged PT, normal APTT

D. Normal PT and APTT

Fibrin monomers are increased in which of the following conditions?

A. Primary fibrinolysis

B. DIC

C. Factor VIII deficiency

D. Fibrinogen deficiency

Fibrin monomers are increased in which of the following conditions?

A. Primary fibrinolysis

B. DIC

C. Factor VIII deficiency

D. Fibrinogen deficiency

Which of the following is associated with multiple factor deficiencies?

A. An inherited disorder of coagulation

B. Severe liver disease

C. Dysfibrinogenemia

D. Lupus anticoagulant

Which of the following is associated with multiple factor deficiencies?

A. An inherited disorder of coagulation

B. Severe liver disease

C. Dysfibrinogenemia

D. Lupus anticoagulant

Normal PT and APTT results in a patient with poor wound healing may be associated with:

A. Factor VII deficiency

B. Factor VIII deficiency

C. Factor XII deficiency

D. Factor XIII deficiency

Normal PT and APTT results in a patient with poor wound healing may be associated with:

A. Factor VII deficiency

B. Factor VIII deficiency

C. Factor XII deficiency

D. Factor XIII deficiency

Fletcher factor (prekallikrein) deficiency may be associated with:

A. Bleeding

B. Thrombosis

C. Thrombocytopenia

D. Thrombocytosis

Fletcher factor (prekallikrein) deficiency may be associated with:

A. Bleeding

B. Thrombosis

C. Thrombocytopenia

D. Thrombocytosis

One of the complications associated with a severe hemophilia A is:

A. Hemarthrosis

B. Mucous membrane bleeding

C. Mild bleeding during surgery

D. Immune-mediated thrombocytopenia

One of the complications associated with a severe hemophilia A is:

A. Hemarthrosis

B. Mucous membrane bleeding

C. Mild bleeding during surgery

D. Immune-mediated thrombocytopenia

The most common subtype of classic von Willebrand disease is:

A. Type 1

B. Type 2A

C. Type 2B

D. Type 3

The most common subtype of classic von Willebrand disease is:

A. Type 1

B. Type 2A

C. Type 2B

D. Type 3

Prolonged APTT and PT are corrected when mixed with normal plasma. Which factor is most likely deficient?

A. Factor VIII

B. Factor V

C. Factor XI

D. Factor IX

Prolonged APTT and PT are corrected when mixed with normal plasma. Which factor is most likely deficient?

A. Factor VIII

B. Factor V

C. Factor XI

D. Factor IX