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what puts constraint on animal form and function?
evolution and natural selection
ICF
intrecellular fluid. the fluid that is contained in cells. makes up 2/3 of the body's water
ECF
extracellular fluid. makes up the remaining 1/3 of the body's fluid. 75% is interstitial fluid, 25% is plasma.
advantages of multicellularity
allow for complex organisms to evolve because different cellular functions can exist.
allows cells a better chance at surviving because they can rely on eachother
what are the two barriers?
cell membranes: a barrier into and out of the cell
epithelia: control movement into and out of organs and tissues
epithelial tissue
protect, absorb, secrete
line the insides of organs and blood vessels and the outside of the body. SENSORY FUNCTION
nervous tissue
signal transduction, communciation throughout the body.
muscle tissue
movement and support
connective tissue
serves to connect the entire body. adipose tissue, blood, bones. also helps with support
the type of connective tissue is determined by concentration of ECF
central theme of physiology
homeostasis
positive feedback
amplifies the stimulus that creates the error message
birth, urination, sexual climax, molting
negative feedback
the response serves to dampen the stimulus that is creating the error message. examples are some hormone pathways, temeprature, stress levels (cortisol)
endotherms
get heat from metabolic processes. regulators. increased metabolic rate to compensate for temperature changes in environment and the need to regulate their internal temperature.
ectotherms
regulate their temperature to that of the environment. have low metabolic rates, but they do increase slowly as temperature increases.
cellular respiration
12h2o+6co2=glucose+6O2
what happens to CO2 in water
it becomes carbonic acid, which then dissociates into bicarbonate and ions, which go to the lungs, reform CO2, and get breathed out
what way does gas flow
down the partial pressure gradient
what percent of air is oxygen
21%
what gas diffuses more easily into water?
CO2 because of dipoles
oxygen
oxygen is easier to get from the air because air is less viscous and less dense than water, air also contains about 20X the amount of oxygen as water.
summary of the transport of gases in the body
inhalation (bulk flow)
diffusion across epithelial cells
circulation (bulk flow)
diffusion across epithelial surfaces into tissues
ficks equation
q=da(p1-p2)/l
q=flow rate
d=diffusion constant
a=cross sectional area of membrane
p1-p2=pp difference
l=membrane thiccness
kroghs rule
states that oxygen can diffuse over distances smaller or equal to .5mm
flatworms and sponges (breathing)
kroghs rule. rely on simple diffusion
how do amphibians breath
through their skin (high water loss, but works in water and in the air)
close their mouth to use positive pressure to get air into lungs. countercurrent gas exchange in vessels. bidirectional/tidal air flow.
how do birds breath
unidirectional air flow over respiratory organs. increases partial pressure difference
first breath: air is breathed in and goes to posterior air sacs
first exhale: air is moved from posterior air sas into parabronchi where gas exchange takes place
second inhale: air moves from parabronchi/lungs into the anterior air sacs
second exhale: air is moved out of the bird from the anterior air sacs
birds also have the most efficient respiratory system. they have the thinnest epithelial tissue
countercurrent gas exchange.
how do mammals breathe
negative pressure breathing caused by the diaphragm contracting to pull air into the lungs. countercurrent gas exchange. tidal ventilation. tidal ventilation results in some mixing of air which makes it slightly inefficient.
how do fish breathe
fish use gills which have gill filaments and lamellae. fish force water over their gills and utilize countercurrent gas exchange to extract O2 from the water. UNIDIRECTIONAL
circulatory systems mediate the flow of (6)
gases, salts, hormones, heat, glucose, water
placozoans and flatworms circulatory systems
none because of kroughs rule
nematode circulatory system
open, fluid flows between the two body tubes
arthropod circulatory system
open
vertebrate circ system
need true circualtory systems
elements of a true circulatory system
pump, conduits, fluid. REQUIRES MORE ENERGY THAN OPEN
open circulatory systems
blood and interstitial fluid mix. arthropods, mollusks, insects
hemoglobyn and hemocyanin
use iron/copper to bind O2 to transport because O2 can not diffuse into water
what does a series mean
refers to the order of blood flow, is needed to effectively transport and allow oxygen to diffuse
fish circ system
two chamber heart. only one circuit. blood flows from heart into afferent arterioles. flows to gill capillaries to pick up oxygen. flows to efferent arterioles into the systemic circuit. flows back to heart
reptile circ system
three chambered heart with two atria and one ventricle, although in reptiles the ventricle is largely split. two circuits. deoxygenated blood flows into the right atria, into the ventricle, and then into the pulmonary circuit. oxygenated blood then flows from the lungs to the ventricle again, and then is pumped into the systemic circuit. are able to shunt blood from lungs when needed.
amphibian circ system
three chambers, two atria and one ventricle. one ventricle means oxygenated blood and deoxygenated blood mix which makes it less efficient. deoygenated blood flights into the right atria and into the ventricle, then to the lungs to pick up oxygen. flow back into the left atria and then to the ventricle and then is pushed into the systemic circuit.
mammal and bird circ system
four chambered heart with two atria and two ventricles. this is the most efficient which is good because birds and mammals are endotherms. two circuits. two atria two ventricles. deoxygenated blood flows into the right side and flows to the lungs to pick up oxygen. flows back into the left side, and flows to the systemic circuit.
explain teh path of bloodflow in mammals
deoxygenated blood enters the right atria from the venae cavae. it flow into the right ventricle, passing the AV valve (prevents backflow) the blood is then pushed into the pulmonary artery from the ventricle, passing the pulmonary valve. oxygenated blood then returns through pulmonary VEIN to left atria, passes into ventricle passing the AV valve. blood then passes into the aorta and flows into the systemic circuit
order of conduits
arteries-arterioles-capillaries-venules-veins
explain how a heartbeat spreads
pacemaker cells held in the SA node begin signals, which is then held up at the AV valve to allow blood to fill ventricles (AV valves close). the signal then passes to the apex of the heart through AV BUNDLE. the ventricles then contract
DEPOLARIZATION before contraction
blood flow physics details
the BP is highest in the aorta coming out of the heart. arteries have higher BP than veins. as conduits get smaller, the liquid flow rate decreases to allow for O2 diffusion in capillary beds. at capillaries, cross sectional area is largest because of the capillary beds. BP picks up slightly in veins
veins
have valves. low flow rate. flat cross sections. can act as blood reservoirs. carry blood to heart. deoxygenated blood.
Exception: pulmonary vein has oxygenated blood OTW to heart
what is the relationship between liquid flow rate and vessel diameter
as diameter decreases, resistance increase and flow rate decreases.
arteries
can change diameter as needed. higher BP than veins. have smooth muscle lining to change diameter. round cross sections. have elastin fibers. carry blood away from heart. oxygenated blood
exception: pulm artery has deoxygenated blood OTW to the lungs
vasoconstriction vs vasodilation
vasoconstriction is caused by smooth muscle. this decreases the blood flow to an area. vasodilation increases the blood flow to an area. this allows the organism to choose where to send blood
____ ____ interactions cause muscle movement
protein protein
why do muscles work in opposing pairs
because htey can ONLY contract, they are incapable of 3D movement
sarcomere
the functional unit of muscle.
myofibrils
made up of myofilaments (which contain actin and myosin)
held together by conn tissues
why are skeletal muscle cells multinucleated
because they are a combination of embryonic precursor cells called myoblasts which each had their own nucleus
which bands on the sarcomere change during a contraction?
I and H
muscle cells use ______ and _____ to regulate contractions
action potentials and calcium
what are the six steps of a neuromuscular junction
an action potential spreads from a neuron to the neuromuscular junction which causes voltage gated Ca channels to open which stimulate the release of acetylcholine (skeletal, but it is norep in cardiac) which
opens ligand gated Na channels
depolarization spreads throughout the muscle cell through voltage gated Na channels, spreads down t tubules. voltage gated Ca channels open. Ca released into cytoplasm
explain the role of action potentials and calcium in muscle contraction
APs are propogated from a neuron, which signals the release of neurotransmitters into the synaptic cleft. neurotransmitters open Na channels, which signal to the cell to release calcium. calcium travels down the T tubules and binds to troponin, which moves the tropomyosin and exposes actin binding sites. myosin then binds to actin and releases an inorganic phosphate, causing a powerstroke. this continues. the contraction stops once the calcium has been removed , ATP is released, and the myosin detaches from actin.
T tubules in skeletal muscle
help propogate action potentials, extend into the saroclemma.
type of muscle contracitons of each type of muscle
cardiac: myogenic
smoothe: involuntary
skeletal: voluntary
intercalated discs
connect cardiac muscle cells
gap junctions
connect smooth and cardiac muscle cells to help propogate contraction-- the cells are connected through their cytoplasms
pacemaker cells
begin the contraction in cardiac muscle.
notes on smooth muscle
no sarcomeres because smooth muscle contracts in sheets instead using gap junctions of using the sliding filament model. found on the insides of hollow organs such as the uterus and intestines. can dilate or constrict blood vessels.
parts of a neuron
soma: cell body, big round part
dendrites: the extensions
axon: the single long extension
axon hillock: where the axon connects to the cell body (AP fired here)
axon terminals: end reaches of the axon
concentration of ions in the neurons
there is more POTASSIUM on the inside of the cell, more SODIUM on the outside
Na-K pump
3 Na out, 2 K in
why us the resting potential negative?
leaky POTASSIUM channels--K flows out of the cell
resting potential:
-65 mv. leaky channels are open
depolarization:
cell becomes less negative, sodium flows into the cell
repolarization
at 40 mv, sodium channels close and K channels open, leading to potassium flowing out of the cell. the cell then becomes more negative.
hyperpolarization
once resting potential is reached, K channels close, but the cell over shoots and becomes overly negative. allows for refractory period. fixed by Na K pump.
how to speed up AP propogation
increase the diameter of the axon or use myelin sheath. APs are self propogating and move when the next cell is depolarized.
nerve net
simple. no CPU. in cnidarians and echinoderms.
molluscan nervous systems
cephalized, centralized. anterior brains.
motor (efferent) division of the peripheral NS is broken into
somatic: voluntary.
autonomic: involuntary- heartbeat, breathing, etc
ANS divisions
sympathetic and parasympathetic
sympathetic nervous system
fight or flight. skeletal muscle is used. fast heartbeat. inhibits digestion. dilates pupils. sexual stimulation. fast breathing
parasympathetic division
rest and digest. blood goes to digestive system. orgasm. slower breathing
examples of when the body uses the nervous system
panic (seeing a bear) pain response (burning hand) anything that needs a quick response. use action potentials to communicate
when would the body use the endocrine system
growth, stress, pregnancy. any long term changes.
autocrine signaling
the cell communicates with itself
paracrine signaling
the cell communicates with nearby cells
pheromone signaling
chemical signaling to a different organism (outside of organism)
neurotransmitters vs hormones
NT: used to communicate with adjacent cells, cause post synaptic potentials (small)
hormones: travel through blood stream
peptide hormones
can be created ahead of time. stored in vesicles. short half life. attach to the outside of the cell membrane using receptors. released when stimulated HYDROPHILIC
ADH
steroid hormones
hydrophobic. long half lives because they are bound by carrier proteins. can bind to nuclear or cellular membrane. CORTISOL
amines
can have characteristics of peptides or steroids.
neuro secretory cells
controlled by neurons, send message to endocrine tissue
non neural secretory cells
are controlled by hormones themselves. epithelial
pancreas etc
where do most endocrine signals begin
hypothalamus
anterior pituitary
made mostly of non neural cells. releases TROPIC hormones. ACTH
types of hormones released by hypothalamus
releasing or stimulating hormones. go to anterior pit which releases its hormones. CRH
posterior pituitary
axons of neural sectretory cells. releases hormones that act directly on target
what are tropic hormones
hormones that have other endocrine glands as their targets
ADH
distal tubules.
high ADH=lots of aquaporins
negative feedback loop
diuresis
produces a lot of dilute urine. low ADH, few aquaporins.
anti diruresis
low amounts of very concentrated urine. a lot of aquaporins, high ADH. conserves water.
U/P ratios
all animals can make dilute urine (U/P<1) but only mammals and birds can make concentrated urine (U/P>1, dilute ECF)
why does the amount of water availabe determine how an organism gets rid of ammonia
ammonia water soluble and therefore is easier to apss the more water an organism has