Ochem Substitution and Elimination

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Last updated 2:08 PM on 4/3/26

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1

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Primary Halide + Strong Nucleophile

Sn2

2

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Primary halide + bulky base

E2

3

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Secondary halide + strong base/nu

E2 (major) and Sn2 (minor)

4

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Secondary halide + weak base/nu

Sn1/E1

5

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Tertiary halide + strong base

E2

6

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Tertiary halide + weak base/nucleophile

Sn1/E1 (Heat favors E1)

7

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Bulky Base

E2 (Hoffman product formed)