ageing models in yeast

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Last updated 5:53 PM on 5/12/26
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8 Terms

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What is Replicative Life Span (RLS) in yeast?

The number of mitotic divisions a mother cell undergoes before senescence.

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What limits RLS in yeast?

Accumulation of Extrachromosomal rDNA Circles (ERCs).

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How is RLS measured?

Via micromanipulation (every ~90 minutes).

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What human cell type does RLS model?

Mitotically active cells (e.g., stem cells).

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What is Chronological Life Span (CLS) in yeast?

The length of time non-dividing cells remain viable in stationary (G0) phase.

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How is CLS measured?

Via CFUs or Phloxin B staining.

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What human cell type does CLS model?

Post-mitotic cells (e.g., neuron