Chapter 19 Hell

Nocardia

Transported through Respiratory Droplets
Lives in Soil
Immunocompromised people at Risk
Can Cause Pulomary Disease Similar to TB

Actinomyces Israelii. Whats the Morphology also?

Swollen Tender nodules in the neck or Jaw, Swollen Lymph Nodes

Looks like filamentous rods under the microscope

Some Characteristics of Actinomycetes Israelii

Filamentous Bacilli
Not Motile
Enters through oral mocous membrane

Discharge Contains sulfur granules
Display a Mycelium like growth

DERIVES FROM MICROBIOTA

Paucibacillary Hansens Disease

Asymmetrical Shallow Skin Lesions

Feather Test

Hansen Disease Relation

MultiBacillary Hansens Disease

Can get secondary infections
End up with respiratory/kidney failure
Disfiguring of body
Folds on the skin cooler parts like groin
Granulomatous thickings.

Anthrax Spread

Skin, Pulmonary, Gi

Anthrax

Is Zoonotic
Is fatal, causing septiciemia and toxemia
Found in Africa, Asia, Middle East , Sporadic in the US

Bacillus anthracis

Capsule and Extoxins, and Gram Positive

Gram Positive Endorspore

Clostrdium

Gram positive non Endospore forming bacilli

Listeria, Eryspielothorix (LP)

Bacilluius vs Colstrdium

Aerobic and Catalase positive - Baciullius Opposite is colstridium

Bacillus Antharcis

Grazing Animals, infecting soil

Eschar is in

Cutaneous Eschar

Woolsorters disease

Is in Pulmonary Anthrax

Food borne Neurotoxin

Botulism

Colstridoides

Enterotoxins produced damaging intenstines

Colstrdium Tetani

Paralysis (Like tetnus)

Actelycholine Prevented by

Colstridium Botulism

Colstridium Perfrigens

Deep Wounds, Muscle Necrosis

Botulin Produced in

Anaerobic

Tetanus

Treated by Antitoxin Therapy with Immunogobolin

Food borne Botulism

antitoxin threapy

Listeriosis

Fever, Diarrhea, Sore throat

Serious stuff is Septicemia, Meninigtis, In elder people
Death of the fetus

Lesson the risk of Listerisosis

Adequate Paseurization and throughly cook food (Milk stuff)

Erysipeloid

Transmitted through skin abrasions, infected swine

Pseduomembrane leads to

Diptheria

Preventing Diptheria

D-TaP immunization

Corynebacterium Diphtheriaes primary virulence factor

Exotoxin, Serious problems

Mycobacterium

All are NOT human pathogens

Mycobacterium TB

Complex Waxy Lipids in the cell, Cord factor that prevents destruction via lysomes and macrophages

TB?!?!

Can Reactivate
Some are Greenish, Or Bloody Sputum, Anorexia, Weight Loss, Night Sweats

Extrapulmonary TB

Moves away from the Lungs, goes to lone bones gential tract

TB Prevented in other countries

BCG Vaccine

TB Will be Positve..

Active TB, Or TB Exposed previously

Injections Take Place for TB

Intradermally

PPD -

Purified Protein Deratitive

TB Diagnosises?

Mantoux
Acid Fast
Chest X-Ray
Sputum Culture
Tubercullin Skin Test

You CANNOT….

Culture the pathogen that causes Hansens Disease

causes fish tank granuloma?

1. Mycobacterium marinum

Look a Like to TB

Mycobacterium kansasii

M.Larpae

Armadillo Carrys Larping

Dipheteria IS

NOT ZOONOTIC

most at risk for botulism?

Home Preserved Food

How would you treat gangrene?

1. Amputation

2. Oxygen therapy

3. Hyperbaric chamber

4. Rigorous cleaning